{"ok":true,"entry":{"slug":"itraconazole","kind":"medication","name":"itraconazole","aliases":["Sporanox"],"brands_sg":["Sporanox","Canditral","Unitrac"],"class":"azole antifungal","tags":["other"],"use_for":"fungal infections of skin, nails, mouth and organs (sg)","use_after":"healthhub: immediately after a full meal, swallowed whole","use_duration":null,"take_with":"a full meal · healthhub: no alcoholic drinks while on it","pros":["sg label: nail, skin and systemic fungal infections","healthhub: taken right after a full meal for absorption","us label: 200 mg once daily is the usual starting dose"],"cons":["sg label: pregnancy only in life-threatening cases","sg label: not with heart failure, now or in the past","healthhub: clashes with statins, digoxin and midazolam"],"dose_note":"the us sporanox capsule label carries the ceiling: ‘the recommended dose is 200 mg once daily (2 capsules). If there is no obvious improvement … the dose should be increased in 100-mg increments to a maximum of 400 mg daily’, with ‘doses above 200 mg/day should be given in two divided doses’ and a 3-day exception in life-threatening situations — ‘a loading dose of 200 mg (2 capsules) three times daily (600 mg/day) … for the first 3 days’. the singapore national drug formulary entry for sporanox carries no mg figures at all, only ‘for optimal absorption, administer sporanox capsules immediately after a full meal’. every sg capsule is 100 mg. as directed on the label or by your doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnancy or planning one — sg label: contraception advised","heart failure now or in the past — sg label: contraindicated","liver or kidney problems — sg label: limited data, caution","healthhub: every other medicine, herbal or supplement counts"],"clashes":[{"src":["hh_itra_int"],"note":"healthhub: blood levels of these may be increased when taken with itraconazole","with":"digoxin, midazolam and ciclosporin"},{"src":["hh_itra_int"],"note":"healthhub: risk of muscle weakness if combined with cholesterol-lowering drugs","with":"statins such as simvastatin and atorvastatin"},{"src":["hh_itra_int"],"note":"healthhub: these can lower itraconazole blood levels, making it less effective","with":"phenytoin and rifampicin"},{"src":["ndf_sporanox_contra"],"note":"sg label: co-administration of a number of these is contraindicated — risk of torsade de pointes","with":"cyp3a4 substrates that prolong the qt interval"},{"src":["hh_itra_se"],"food":true,"note":"healthhub: alcoholic drinks are to be avoided while taking this medication","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 4 registered itraconazole products read 'Prescription Only' — SIN08206P SPORANOX CAPSULE 100 mg · SIN11355P CANDITRAL CAPSULE 100 mg · SIN12459P UNITRAC CAPSULE 100 mg · SIN16379P JAMP ITRACONAZOLE ORAL SOLUTION 10MG/ML","accessed":"2026-08-27"},{"id":"hh_itra_use","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/itraconazole","label":"HealthHub (MOH Singapore) — Itraconazole: what it is for and how to take it (reviewed 21 Jan 2026)","quote":"Itraconazole is used to treat fungal infections … Itraconazole should be taken immediately after a full meal. Capsules should be swallowed whole. Complete the course as prescribed by the doctor.","accessed":"2026-08-27"},{"id":"hh_itra_int","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/itraconazole","label":"HealthHub (MOH Singapore) — Itraconazole: precautions and drug interactions","quote":"The amount or levels of digoxin, midazolam and cyclosporine in the blood may be increased … risk of muscle weakness if combined with cholesterol lowering drugs such as simvastatin or atorvastatin … phenytoin and rifampicin can decrease the blood level","accessed":"2026-08-27"},{"id":"hh_itra_pre","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/itraconazole","label":"HealthHub (MOH Singapore) — Itraconazole: precautions on pregnancy and contraception","quote":"Effective contraception is recommended for any woman who is taking itraconazole, and who could potentially become pregnant during treatment and for 2 months following the end of treatment.","accessed":"2026-08-27"},{"id":"hh_itra_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/itraconazole","label":"HealthHub (MOH Singapore) — Itraconazole: common side effects, food and drink","quote":"Some side effects of these medications include: Nausea, vomiting, stomach upset … Diarrhoea … Headache … Avoid alcoholic drinks while you are taking this medication.","accessed":"2026-08-27"},{"id":"ndf_sporanox_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/SIN08206P","label":"National Drug Formulary (SG, MOH) — SPORANOX CAPSULE 100 MG [SIN08206P]: approved indications","quote":"Treatment of dermatomycosis, including highly keratinized regions as in plantar tinea pedis and palmar tinea manus; Treatment of pityriasis versicolor; Treatment of oral candidosis … Treatment of onychomycosis … systemic aspergillosis and candidosis","accessed":"2026-08-27"},{"id":"ndf_sporanox_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/SIN08206P","label":"National Drug Formulary (SG, MOH) — SPORANOX CAPSULE 100 MG [SIN08206P]: dosage and administration","quote":"For optimal absorption, administer SPORANOX capsules immediately after a full meal. The capsules must be swallowed whole … Optimal clinical and mycological response is thus reached 2 to 4 weeks after the cessation of treatment for skin infections","accessed":"2026-08-27"},{"id":"ndf_sporanox_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/SIN08206P","label":"National Drug Formulary (SG, MOH) — SPORANOX CAPSULE 100 MG [SIN08206P]: contraindications","quote":"SPORANOX capsules must not be used during pregnancy (except for life-threatening cases) … should not be administered to patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF","accessed":"2026-08-27"},{"id":"fda_sporanox","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22SPORANOX%22+AND+openfda.route:%22ORAL%22&limit=3","label":"US FDA label — SPORANOX (itraconazole) Capsules, DOSAGE AND ADMINISTRATION, via openFDA","quote":"The recommended dose is 200 mg once daily (2 capsules) … the dose should be increased in 100-mg increments to a maximum of 400 mg daily. Doses above 200 mg/day should be given in two divided doses.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}