{"ok":true,"entry":{"slug":"insulin-degludec","kind":"medication","name":"insulin degludec","aliases":["Tresiba"],"brands_sg":["Tresiba"],"class":"ultra-long-acting insulin","tags":["diabetes"],"use_for":"sg label: diabetes mellitus in adults and ages 12–17","use_after":"sg label: once daily, any time of day, preferably the same","use_duration":null,"take_with":"injected under the skin — thigh, upper arm or abdomen","pros":["sg label: dosing time can flex, min 8 h between doses","sg label: registered in sg at 100 u/ml and 200 u/ml","us label: u-100 pen gives up to 80 units per injection"],"cons":["us label: hypoglycaemia may be life-threatening","us label: hypokalaemia may be life-threatening","sg label: not for insulin pumps, and never given iv"],"dose_note":"neither label prints a maximum daily dose. the sg tresiba insert (sin15703p) says \"tresiba is to be dosed in accordance with the individual patient's needs\" and the only ceilings it gives are the pen's: \"with tresiba 100 units/ml a dose of 1–80 units per injection, in steps of 1 unit, can be administered. with tresiba 200 units/ml a dose of 2–160 units per injection, in steps of 2 units, can be administered\". the us tresiba label repeats the same device limits — the u-100 flextouch \"can deliver up to 80 units in a single injection\" and the u-200 \"up to 160 units in a single injection\". for starting points the sg label states \"the recommended daily starting dose is 10 units\" in type 2 diabetes, and both labels ask for \"a minimum of 8 hours between injections\". in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["an episode of low blood sugar — a contraindication on both labels","kidney or liver impairment — sg label asks for intensified glucose monitoring","a change of insulin strength, brand, type or injection site — us label asks for close medical supervision","sharing a pen or needle — us label: never share, even if the needle is changed"],"clashes":[{"src":["fda_tresiba_di"],"note":"us label lists these among drugs that may increase the risk of hypoglycaemia","with":"other diabetes medicines, ace inhibitors, arbs, fibrates, fluoxetine, salicylates"},{"src":["fda_tresiba_di"],"note":"us label lists these among drugs that may decrease the blood-glucose-lowering effect","with":"corticosteroids, diuretics, oestrogens, oral contraceptives, thyroid hormones"},{"src":["fda_tresiba_di"],"note":"us label: these may blunt the signs and symptoms of hypoglycaemia","with":"beta blockers, clonidine, guanethidine, reserpine"},{"src":["fda_tresiba_di"],"food":true,"note":"us label lists these among drugs that may increase or decrease the effect","with":"alcohol and lithium salts"},{"src":["fda_tresiba_warn"],"note":"us label: fluid retention and heart failure with concomitant use","with":"thiazolidinediones (tzds)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/api/action/datastore_search?resource_id=d_767279312753558cbf19d48344577084&limit=6000","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 27 Aug 2026","quote":"TRESIBA FLEXTOUCH PRE-FILLED PEN 100 U/ML SIN15703P and 200 U/ML SIN15704P, Insulin Degludec, ATC A10AE06, both Prescription Only; RYZODEG FLEXTOUCH 100 U/ml SIN15706P, Insulin Aspart&&Insulin Degludec, ATC A10AD06, Prescription Only","accessed":"2026-08-27"},{"id":"ndf_tresiba","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15703p/","label":"MOH National Drug Formulary (Singapore) — TRESIBA FLEXTOUCH 100 U/ML [SIN15703P], product information","quote":"INSULIN DEGLUDEC - 100 UNITS/ML … Registration Number SIN15703P … Licence Holder NOVO NORDISK PHARMA (SINGAPORE) PTE LTD … Forensic Classification PRESCRIPTION ONLY MEDICINES … ATC code A10AE06","accessed":"2026-08-27"},{"id":"ndf_tresiba_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15703p/","label":"MOH National Drug Formulary (Singapore) — TRESIBA [SIN15703P], Therapeutic indications","quote":"Treatment of diabetes mellitus in adults and adolescents from the age of 12–17 years","accessed":"2026-08-27"},{"id":"ndf_tresiba_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15703p/","label":"MOH National Drug Formulary (Singapore) — TRESIBA [SIN15703P], Posology","quote":"a basal insulin for once-daily subcutaneous administration at any time of the day, preferably at the same time every day … a dose of 1–80 units per injection … A minimum of 8 hours between injections should always be ensured","accessed":"2026-08-27"},{"id":"ndf_tresiba_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15703p/","label":"MOH National Drug Formulary (Singapore) — TRESIBA [SIN15703P], Method of administration","quote":"Tresiba is for subcutaneous use only … must not be administered intravenously … must not be used in insulin infusion pumps … administered subcutaneously by injection in the thigh, the upper arm or the abdominal wall","accessed":"2026-08-27"},{"id":"fda_tresiba_ind","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRESIBA%22&limit=2","label":"TRESIBA (insulin degludec) injection — US prescribing information, openFDA drug label record (Novo Nordisk), Indications","quote":"TRESIBA is a long-acting human insulin analog indicated to improve glycemic control in patients 1 year of age and older with diabetes mellitus … Not recommended for the treatment of diabetic ketoacidosis","accessed":"2026-08-27"},{"id":"fda_tresiba_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRESIBA%22&limit=2","label":"TRESIBA (insulin degludec) injection — US prescribing information, Dosage and Administration: device ceilings","quote":"The FlexTouch pen delivers doses in 1 unit increments and can deliver up to 80 units in a single injection … TRESIBA U-200 … can deliver up to 160 units in a single injection","accessed":"2026-08-27"},{"id":"fda_tresiba_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRESIBA%22&limit=2","label":"TRESIBA (insulin degludec) injection — US prescribing information, Warnings and Precautions","quote":"Never share a TRESIBA FlexTouch pen, insulin syringe, or needle between patients, even if the needle is changed … Hypoglycemia: May be life-threatening … Hypokalemia: May be life-threatening … Fluid retention and heart failure with concomitant use of Thiazolidinediones","accessed":"2026-08-27"},{"id":"fda_tresiba_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRESIBA%22&limit=2","label":"TRESIBA (insulin degludec) injection — US prescribing information, Contraindications","quote":"TRESIBA is contraindicated: During episodes of hypoglycemia … In patients with hypersensitivity to insulin degludec or any of the excipients in TRESIBA","accessed":"2026-08-27"},{"id":"fda_tresiba_di","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22TRESIBA%22&limit=2","label":"TRESIBA (insulin degludec) injection — US prescribing information, Drug Interactions (Table 5)","quote":"Drugs That May Increase the Risk of Hypoglycemia … ACE inhibitors, angiotensin II receptor blocking agents … fibrates, fluoxetine … salicylates … Drugs That May Decrease the Blood Glucose Lowering Effect … corticosteroids, danazol, diuretics, estrogens … thyroid hormones","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:23.779398+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}