{"ok":true,"entry":{"slug":"hyoscine-hydrobromide","kind":"medication","name":"hyoscine hydrobromide","aliases":["scopolamine","Kwells","Scopoderm"],"brands_sg":[],"class":"antimuscarinic antiemetic","tags":["digestive"],"use_for":"travel and motion sickness — nausea and vomiting","use_after":"nhs: a dose 20–30 min before a journey; patch 5–6 h","use_duration":null,"take_with":"tablets sucked, chewed or swallowed, with or without food","pros":["uk label: for the prevention of travel sickness","nhs: pharmacies sell 150 and 300 microgram tablets","nhs: one patch can stay on for up to 72 hours"],"cons":["not on the hsa register — no sg-registered product","uk label: drowsiness, dry mouth, blurred vision","uk label: glaucoma or prostate enlargement rules it out"],"dose_note":"the uk spc for kwells 300 microgram tablets (hyoscine hydrobromide) states, for adults, \"1 tablet every 6 hours if required. Do not take more than 3 tablets in 24 hours\" — three 300-microgram tablets, so 900 micrograms, is the adult 24-hour label ceiling; the same section gives children over 10 \"½-1 tablet every 6 hours if required. Do not take more than 1½-3 tablets in 24 hours\". for the patch form (scopoderm), nhs says a patch can be kept on for up to 72 hours and \"Do not apply more than 1 patch at a time\". there is no singapore label to quote: hsa has no registered hyoscine hydrobromide product, so any pack found here is an overseas one and its own leaflet is the only label that applies.","dosage":null,"ul_status":null,"sg_class":null,"cautions":["glaucoma, prostate enlargement, paralytic ileus or myasthenia gravis — uk label contraindications","heart, thyroid, kidney or liver problems (nhs)","epilepsy — the uk label reports rare rises in seizure frequency","pregnancy — nhs says it is not recommended"],"clashes":[{"src":["emc_kwells_int"],"note":"uk label: effects of hyoscine may be enhanced, and combining them should be avoided","with":"other anticholinergic medicines (amantadine, some antihistamines, phenothiazines, tricyclics)"},{"src":["emc_kwells_int"],"note":"uk label: increased risk of side effects through inhibition of drug-metabolising enzymes","with":"mao inhibitors"},{"src":["emc_kwells_int"],"food":true,"note":"uk label: the sedative effect of the tablets may be enhanced","with":"alcohol and cns depressants"},{"src":["emc_kwells_int"],"note":"uk label: antagonism of their effect on gastro-intestinal activity","with":"domperidone and metoclopramide"},{"src":["emc_kwells_int"],"note":"uk label: reduced effect, as a dry mouth stops the tablet dissolving under the tongue","with":"sublingual nitrate tablets"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), all 5,511 rows cached at /tmp/hsa_all.json and filtered locally, never re-fetched","quote":"Zero rows match \"hyoscine hydrobromide\" or \"scopolamine\". All 10 \"HYOSCINE\" rows are HYOSCINE BUTYLBROMIDE or HYOSCINE N-BUTYLBROMIDE, ATC A03BB01 — a different salt (BUSCOPAN, DHACOPAN, HYOMIDE, SPASMOLIV, FUCON, HYOSUN, COSPAN, COPAN).","accessed":"2026-08-27"},{"id":"nhs_hyo_hub","url":"https://www.nhs.uk/medicines/hyoscine-hydrobromide/","label":"NHS — Hyoscine hydrobromide (Kwells and Joy-Rides), medicine landing page","quote":"Hyoscine hydrobromide (Kwells and Joy-Rides) - Other brand names: Kwells Kids, Travel Calm, Scopoderm. Find out how hyoscine hydrobromide treats travel sickness and how to take it.","accessed":"2026-08-27"},{"id":"nhs_hyo_how","url":"https://www.nhs.uk/medicines/hyoscine-hydrobromide/how-and-when-to-take-hyoscine-hydrobromide/","label":"NHS — How and when to take hyoscine hydrobromide: tablets","quote":"Pharmacies sell 2 different strengths … 150 micrograms … 300 micrograms … a dose at least 20 to 30 minutes before starting your journey … Suck or chew the tablets, or swallow them whole … with or without food.","accessed":"2026-08-27"},{"id":"nhs_hyo_patch","url":"https://www.nhs.uk/medicines/hyoscine-hydrobromide/how-and-when-to-take-hyoscine-hydrobromide/","label":"NHS — How and when to take hyoscine hydrobromide: patches for travel sickness","quote":"Stick a patch to the skin behind the ear, 5 to 6 hours before the start of your journey … keep the patch on for up to 72 hours … Do not apply more than 1 patch at a time.","accessed":"2026-08-27"},{"id":"nhs_hyo_who","url":"https://www.nhs.uk/medicines/hyoscine-hydrobromide/who-can-and-cannot-take-hyoscine-hydrobromide/","label":"NHS — Who can and cannot take hyoscine hydrobromide","quote":"tell a pharmacist or doctor before taking it if you … have primary angle closure glaucoma … myasthenia gravis … heart problems … thyroid, kidney or liver problems … epilepsy … are pregnant or trying to get pregnant","accessed":"2026-08-27"},{"id":"emc_kwells_ind","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, sections 1–4.1, Dexcel-Pharma, revised 19/11/2025","quote":"Kwells 300 microgram tablets … Hyoscine Hydrobromide 300 microgram … Therapeutic indications: For the prevention of travel sickness.","accessed":"2026-08-27"},{"id":"emc_kwells_dose","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, section 4.2 Posology and method of administration","quote":"Tablets to be sucked, chewed or swallowed. Adults: 1 tablet every 6 hours if required. Do not take more than 3 tablets in 24 hours. Children over 10: ½-1 tablet every 6 hours if required.","accessed":"2026-08-27"},{"id":"emc_kwells_ci","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, section 4.3 Contraindications","quote":"Prostatic enlargement, paralytic ileus, pyloric stenosis, glaucoma and myasthenia gravis. In addition, Kwells should not be given to patients with a known sensitivity to hyoscine hydrobromide or any other component of the product.","accessed":"2026-08-27"},{"id":"emc_kwells_warn","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, section 4.4 Special warnings and precautions for use","quote":"those at risk of acute urinary retention, or with cardiovascular, metabolic, gastrointestinal, liver or renal disease, or suffering from CNS disorders such as seizures should consult a doctor … Hyperthermia can occur at high ambient temperatures due to decreased sweating","accessed":"2026-08-27"},{"id":"emc_kwells_ae","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, section 4.8 Undesirable effects","quote":"blurred vision, mydriasis … dry mouth … drowsiness, dizziness, sedation and somnolence are commonly reported … There have been rare reports of an increase in seizure frequency in epileptic patients.","accessed":"2026-08-27"},{"id":"emc_kwells_int","url":"https://www.medicines.org.uk/emc/product/11746/smpc","label":"emc (UK SmPC) — Kwells 300 microgram tablets, section 4.5 Interaction with other medicinal products","quote":"effects of hyoscine may be enhanced by other drugs with anticholinergic properties (including amantadine, some antihistamines, phenothiazine antipsychotics and tricyclic antidepressants) … increased risk of side effects when given with MAOIs … antagonism of effect of domperidone and metoclopramide","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}