{"ok":true,"entry":{"slug":"gotu-kola","kind":"supplement","name":"gotu kola","aliases":["Centella asiatica","pegaga"],"brands_sg":["Life Extension","Swanson Vitamins","Nature's Way","NOW Foods","Nature's Answer"],"class":"botanical","tags":["cognitive","skin-hair"],"use_for":"alertness and mood, rather than cognition itself","use_after":"mood shifts were measured 1 hour after a dose","use_duration":null,"take_with":null,"pros":["alert scores rose vs placebo (smd 0.71)","wrinkle depth fell 11.1% from baseline on 200 mg/day","no adverse effects reported in the pooled rcts"],"cons":["no significant gain in any cognitive domain","skin gains in hydration and elasticity were modest","dose, preparation and standardisation vary widely"],"dose_note":"the cognition review pooled 5 rcts of c. asiatica alone; a separate skin trial used 200 mg a day for 12 weeks","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["not listed in hsa's annexes — that is not a safety clearance","extracts differ; trial results may not transfer between products"],"clashes":[],"sources":[{"id":"puttarak2017","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5587720/","label":"Effects of Centella asiatica on cognitive function and mood: systematic review and meta-analysis (Puttarak et al., Sci Rep 2017)","quote":"Meta-analysis indicated that there are no significant differences in all cognitive function domains of C. asiatica when compared to placebo. However, it could improve mood by increasing alert scores … None of the studies reported adverse effects","accessed":"2026-08-27"},{"id":"puttarak2017_limits","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5587720/","label":"Centella asiatica and cognition — effect size, timing and limitations (Puttarak et al. 2017)","quote":"increasing alert scores [SMD: 0.71 (95% CI; 0.01 to 1.41)] … at 1 hour after treatment … limitations should be aware including dose regimen, plant preparation, standardization, and product variation","accessed":"2026-08-27"},{"id":"centella_skin2026","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13209926/","label":"Oral Centella asiatica extract and skin aging: randomised, double-blind, placebo-controlled trial (Nutrients 2026)","quote":"A total of 112 participants were randomized to receive either Centella asiatica extract (200 mg/day) or placebo for 12 weeks … Average wrinkle depth decreased by 11.1% … changes in skin hydration, elasticity, and brightness were modest","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025, GL-CHPB-1-012)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026, GL-CHPB-3-001 Rev. 020), Tables 4–5","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/gotu-kola","label":"iHerb Singapore — category listing (default order)","quote":"Gotu Kola: Capsules, Extracts & Skin Support | iHerb","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:21.812539+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}