{"ok":true,"entry":{"slug":"gliclazide","kind":"medication","name":"gliclazide","aliases":["Diamicron"],"brands_sg":["Diamicron","Glizide","Dianorm","Melicron","Gliclada"],"class":"sulfonylurea","tags":["diabetes"],"use_for":"prescribed to lower high blood sugar in type 2 diabetes","use_after":"healthhub: immediately before meals, once or twice daily","use_duration":null,"take_with":"a meal · nhs: after food helps avoid stomach problems","pros":["nhs: most people take it once or twice a day","healthhub: works alongside diet and exercise changes","sg register: 30, 60 and 80 mg strengths are listed"],"cons":["healthhub: low blood sugar and weight gain are common","nhs: stomach pain and diarrhoea are common","nhs: not usually used in pregnancy or breastfeeding"],"dose_note":"the uk smpc for diamicron 80 mg tablets states 'The total daily dose may vary from 40 to 320 mg taken orally' and that 'A single dose should not exceed 160 mg (2 tablets)'; the separate smpc for diamicron 30 mg modified-release tablets states 'The maximum recommended daily dose is 120 mg'. the two ceilings are not interchangeable — they belong to different formulations. sg-registered strengths are 30, 60 and 80 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["nhs: severe kidney or liver disease","healthhub: g6pd deficiency, or a sulfa allergy","nhs: acute porphyria","healthhub: age over 65 — higher risk of side effects"],"clashes":[{"src":["nhs_glic_mix","emc_diamicron80"],"note":"nhs lists them among medicines that may not mix well; the smpc allows combination under medical supervision","with":"insulin and other blood sugar medicines"},{"src":["nhs_glic_mix"],"note":"nhs lists weight loss medicines among those that may not mix well","with":"semaglutide or tirzepatide"},{"src":["nhs_glic_mix"],"note":"nhs lists some antibiotics among medicines that may not mix well","with":"clarithromycin and some antibiotics"},{"src":["nhs_glic_mix"],"note":"nhs lists them among medicines that may not mix well","with":"some blood pressure or heart failure medicines"},{"src":["hh_glic_food","nhs_glic_food"],"food":true,"note":"healthhub: flushing, nausea, vomiting, headache, fast heartbeat and giddiness; nhs: it can affect blood sugar","with":"alcohol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 15 registered single-ingredient gliclazide products carry Forensicclassification 'Prescription Only', ATC A10BB09 — SIN04316P DIAMICRON TABLET 80 mg · SIN11868P GLIZIDE · SIN10123P DIANORM · SIN11662P MELICRON · SIN15253P GLICLADA MR 60MG · SIN11761P/SIN13868P DIAMICRON MR 30 mg and 60mg.","accessed":"2026-08-27"},{"id":"nhs_glic_about","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: what gliclazide is for","quote":"Gliclazide is a medicine used to lower high blood sugar levels if you have type 2 diabetes. It's only available with a prescription … Gliclazide works by increasing how much insulin your body makes","accessed":"2026-08-27"},{"id":"nhs_glic_howto","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: how to take gliclazide","quote":"Most people need to take gliclazide once or twice a day … swallow tablets whole with a glass of water … take your tablets after a meal to help avoid stomach problems","accessed":"2026-08-27"},{"id":"nhs_glic_side","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: side effects","quote":"Common side effects of gliclazide include: stomach pain; diarrhoea. If you take gliclazide it may cause low blood sugar (hypoglycaemia, or a \"hypo\").","accessed":"2026-08-27"},{"id":"nhs_glic_who","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: who can and cannot take it","quote":"it may not be suitable for you if: you've ever had an allergic reaction or serious side effect from gliclazide or a similar medicine; you have severe kidney or liver disease; you have acute porphyria","accessed":"2026-08-27"},{"id":"nhs_glic_preg","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: pregnancy and breastfeeding","quote":"Gliclazide is not usually used while breastfeeding … Gliclazide is not usually used during pregnancy. Your doctor may offer you a different medicine while you're pregnant.","accessed":"2026-08-27"},{"id":"nhs_glic_mix","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: taking it with other medicines","quote":"other medicines for high blood sugar, such as insulin; weight loss medicines, such as semaglutide or tirzepatide (Mounjaro); some antibiotics, such as clarithromycin; some medicines for high blood pressure or heart failure","accessed":"2026-08-27"},{"id":"nhs_glic_food","url":"https://www.nhs.uk/medicines/gliclazide/","label":"NHS Medicines A-Z — Gliclazide: food and alcohol","quote":"It's best not to drink alcohol while taking gliclazide because it can affect your blood sugar level.","accessed":"2026-08-27"},{"id":"hh_glic_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/gliclazide","label":"HealthHub (Pharmaceutical Society of Singapore) — Gliclazide: what is this medication for","quote":"Gliclazide is used in the treatment of diabetes. It works together with lifestyle changes, such as having a healthy diet and regular exercise, to reduce blood sugar levels. It helps the pancreas to release more insulin","accessed":"2026-08-27"},{"id":"hh_glic_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/gliclazide","label":"HealthHub — Gliclazide: how should I take or use this medication","quote":"Take the tablet(s) as directed by your doctor immediately before meal(s). Do not miss or delay meals after taking the medication.","accessed":"2026-08-27"},{"id":"hh_glic_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/gliclazide","label":"HealthHub — Gliclazide: precautions","quote":"Have Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency … Are allergic to sulfonamide drugs such as sulfamethoxazole or have a \"sulfa\" allergy … Are an elderly above 65 years old as you have a higher risk of having side effects","accessed":"2026-08-27"},{"id":"hh_glic_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/gliclazide","label":"HealthHub — Gliclazide: common side effects","quote":"The common side effects of Gliclazide include: Low blood sugar (hypoglycemia) … Weight gain. Exercise regularly to prevent weight gain associated with this medication","accessed":"2026-08-27"},{"id":"hh_glic_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/gliclazide","label":"HealthHub — Gliclazide: what food or medication should I avoid","quote":"Avoid taking alcohol with this medication as it may cause symptoms such as flushing, nausea, vomiting, headache, fast heartbeat, fast breathing and giddiness.","accessed":"2026-08-27"},{"id":"emc_diamicron80","url":"https://www.medicines.org.uk/emc/product/1150/smpc","label":"UK SmPC — Diamicron 80mg Tablets (Servier), section 4.2 Posology and method of administration, electronic medicines compendium","quote":"The total daily dose may vary from 40 to 320 mg taken orally. The dose should be adjusted according to the individual patient's response … A single dose should not exceed 160 mg (2 tablets).","accessed":"2026-08-27"},{"id":"emc_diamicron30mr","url":"https://www.medicines.org.uk/emc/product/1321/smpc","label":"UK SmPC — Diamicron 30 mg MR Tablets (Servier), section 4.2 Posology and method of administration, electronic medicines compendium","quote":"The daily dose may vary from 1 to 4 tablets per day, i.e. from 30 to 120 mg taken orally in a single intake at breakfast time … The maximum recommended daily dose is 120 mg.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}