{"ok":true,"entry":{"slug":"fluoxetine","kind":"medication","name":"fluoxetine","aliases":["Prozac"],"brands_sg":["Proctin","Fluxil","Magrilan"],"class":"SSRI antidepressant","tags":["mental-health"],"use_for":"prescribed for depression, ocd, bulimia or anxiety","use_after":"nhs: once a day, at the same time each day","use_duration":null,"take_with":"water · healthhub: with or after food","pros":["nhs: usually once a day","nhs: also prescribed for children aged 5 and over","nhs: comes as tablets, capsules or liquid"],"cons":["nhs: nausea, headache, diarrhoea, sleep problems","nhs: sexual problems and weight changes are common","healthhub: under-25s — mood or behaviour may worsen"],"dose_note":"the us fda label for prozac states 'The maximum fluoxetine dose should not exceed 80 mg/day' in major depressive disorder, and gives 60 mg/day in the morning for bulimia nervosa; it adds that a lower or less frequent dosage should be used in liver impairment, in the elderly and with multiple concomitant medications. sg-registered capsules are 10 mg and 20 mg only. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["epilepsy, diabetes, heart disease or glaucoma (nhs)","a bleeding disorder, or bleeding in the digestive system (nhs)","any past mania or bipolar disorder (nhs, healthhub)","another low-mood medicine in the past 2 weeks (healthhub)"],"clashes":[{"src":["nhs_fluox_mix","hh_fluox_precautions"],"note":"nhs lists maois among medicines that may not mix well; healthhub asks about any low-mood medicine in the past 2 weeks","with":"maoi antidepressants such as moclobemide, selegiline"},{"src":["nhs_fluox_mix","nhs_fluox_side"],"note":"nhs lists anticoagulants; nhs also lists unexplained bruising or bleeding as a serious side effect","with":"warfarin, apixaban and other anticoagulants"},{"src":["nhs_fluox_mix"],"note":"nhs lists nsaids among medicines that may not mix well with fluoxetine","with":"nsaids such as aspirin and ibuprofen"},{"src":["nhs_fluox_mix","hh_fluox_precautions"],"note":"nhs: do not use the herbal supplement st john's wort when taking fluoxetine; healthhub names it too","with":"st john's wort"},{"src":["nhs_fluox_mix"],"note":"nhs lists both among medicines that may not mix well with fluoxetine","with":"tamoxifen, metoprolol"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered offline)","quote":"All 6 registered fluoxetine products carry Forensicclassification 'Prescription Only' — SIN11954P PROCTIN CAPSULE 20 mg · SIN12576P FLUXIL CAPSULE 20 mg · SIN05766P MAGRILAN CAPSULE 20 mg · SIN09317P APO-FLUOXETINE 10 mg. No PROZAC row exists.","accessed":"2026-08-27"},{"id":"nhs_fluox_about","url":"https://www.nhs.uk/medicines/fluoxetine/","label":"NHS Medicines A-Z — Fluoxetine: what fluoxetine is for","quote":"Fluoxetine can be used to treat mental health conditions such as: depression; obsessive compulsive disorder (OCD); bulimia. It can sometimes be used for menopause symptoms. Fluoxetine is a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI).","accessed":"2026-08-27"},{"id":"nhs_fluox_howto","url":"https://www.nhs.uk/medicines/fluoxetine/","label":"NHS Medicines A-Z — Fluoxetine: how to take fluoxetine","quote":"Fluoxetine comes as tablets, capsules or liquid that you swallow … You usually take fluoxetine once a day … take it at the same time each day … you can take it with or without food","accessed":"2026-08-27"},{"id":"nhs_fluox_side","url":"https://www.nhs.uk/medicines/fluoxetine/","label":"NHS Medicines A-Z — Fluoxetine: side effects","quote":"Common side effects of fluoxetine include: headaches; feeling sick (nausea) … diarrhoea or constipation; weight changes; sexual problems, such as low sex drive … problems sleeping … Possible serious side effects … serotonin syndrome … unexplained bruising or bleeding","accessed":"2026-08-27"},{"id":"nhs_fluox_who","url":"https://www.nhs.uk/medicines/fluoxetine/","label":"NHS Medicines A-Z — Fluoxetine: who can and cannot take it","quote":"sometimes used to treat depression in children aged 5 years or older … it may not be suitable if: … diabetes … epilepsy … heart disease … glaucoma … a bleeding disorder … you've ever had mania","accessed":"2026-08-27"},{"id":"nhs_fluox_mix","url":"https://www.nhs.uk/medicines/fluoxetine/","label":"NHS Medicines A-Z — Fluoxetine: taking it with other medicines, food and drink","quote":"antidepressants called monoamine oxidase inhibitors (MAOIs), such as moclobemide and selegiline; metoprolol … tamoxifen … anticoagulants, such as warfarin and apixaban; NSAIDs, such as aspirin and ibuprofen … Do not use the herbal supplement St John's wort","accessed":"2026-08-27"},{"id":"hh_fluox_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fluoxetine","label":"HealthHub (National Medication Information workgroup, SG) — Fluoxetine: what is this medication for","quote":"Fluoxetine belongs to a class of medications known as Selective Serotonin Reuptake Inhibitors (SSRI). It is used to treat symptoms of depression … symptoms of anxiety … obsessive-compulsive disorders, eating disorders and other conditions.","accessed":"2026-08-27"},{"id":"hh_fluox_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fluoxetine","label":"HealthHub — Fluoxetine: how should I take or use this medication","quote":"Fluoxetine should be taken with or after food … needs to be taken regularly for a few weeks before you can feel its full benefits … unpleasant effects … if you suddenly stop taking the medication on your own.","accessed":"2026-08-27"},{"id":"hh_fluox_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fluoxetine","label":"HealthHub — Fluoxetine: precautions and the under-25 warning","quote":"The following changes have been observed in some patients particularly below the age of 25 years taking this medication: New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"fda_prozac_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22PROZAC%22&limit=1","label":"US FDA label for PROZAC (fluoxetine), section 2 Dosage and Administration, via openFDA drug/label.json (effective 2026-01-08)","quote":"Administer doses above 20 mg/day once daily in the morning or twice daily (i.e., morning and noon). The maximum fluoxetine dose should not exceed 80 mg/day.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}