{"ok":true,"entry":{"slug":"fluconazole","kind":"medication","name":"fluconazole","aliases":["Diflucan","Canesten Oral"],"brands_sg":["Diflucan","Medoflucon","Apo-Fluconazole","Omastin","Fungby"],"class":"azole antifungal (oral)","tags":["antibiotic","other"],"use_for":"prescribed for thrush and other candida infections","use_after":"usually once a day · vaginal thrush is a single dose","use_duration":null,"take_with":"water · capsules and liquid work with or without food","pros":["vaginal thrush is one 150 mg dose per nhs","thrush symptoms usually settle within 7 days (nhs)","food optional — with or without a meal (nhs)"],"cons":["nausea and diarrhoea are the most common effects","rare but serious liver injury is a label warning","prescription-only in sg though otc in the uk"],"dose_note":"nhs adult doses: 150 mg as a single dose for vaginal thrush, 50 mg a day for oral thrush, 200–800 mg a day for candida elsewhere. us label: \"Doses up to 400 mg/day may be used\" and, in the children's dose-equivalence table, \"Absolute doses exceeding 600 mg/day are not recommended\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver dysfunction — us label says use with caution; rare fatal hepatic toxicity reported","known hypersensitivity to fluconazole or other azoles — us label contraindication","heart-rhythm risk — qt prolongation and torsade de pointes reported after marketing","kidney dysfunction — us label says use with caution"],"clashes":[{"src":["fda_fluconazole_safety"],"note":"us label contraindication — qt prolongation and torsade de pointes risk","with":"erythromycin, pimozide or quinidine"},{"src":["fda_fluconazole_safety"],"note":"us label: prothrombin time may be increased; warfarin dose may need adjusting","with":"warfarin / coumarin anticoagulants"},{"src":["fda_fluconazole_safety"],"note":"us label: clinically significant hypoglycaemia may be precipitated","with":"sulfonylureas such as glyburide"},{"src":["fda_fluconazole_safety"],"note":"us label: raised risk of myopathy and rhabdomyolysis","with":"statins (atorvastatin, simvastatin)"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (official open dataset on data.gov.sg; full 5,511-row register pulled via the datastore_search API)","quote":"Forensicclassification = \"Prescription Only\" for all 10 fluconazole products on the register (7 oral capsules, 3 intravenous) — SIN06804P/SIN04460P DIFLUCAN CAPSULE, SIN12599P MEDOFLUCON 150, SIN13329P Apo-Fluconazole 150mg, SIN13067P OMASTIN, SIN17396P FUNGBY. No Pharmacy Only row.","accessed":"2026-08-27"},{"id":"nhs_fluc_about","url":"https://www.nhs.uk/medicines/fluconazole/about-fluconazole/","label":"NHS Medicines A–Z — About fluconazole (brand names: Azocan, Diflucan, Canesten Thrush Oral Capsules)","quote":"Fluconazole is an antifungal medicine … available on prescription. You can also buy it from a pharmacy for vaginal thrush or balanitis … symptoms should be better within 7 days … feeling sick (nausea) and diarrhoea.","accessed":"2026-08-27"},{"id":"nhs_fluc_how","url":"https://www.nhs.uk/medicines/fluconazole/how-and-when-to-take-fluconazole/","label":"NHS Medicines A–Z — How and when to take fluconazole","quote":"vaginal thrush or balanitis – 150mg, taken as a single dose · oral (mouth) thrush – 50mg a day … candida infections … 200mg to 800mg a day … You can take fluconazole capsules and liquid with or without food.","accessed":"2026-08-27"},{"id":"fda_fluconazole","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=01df20c4-7b94-044e-e063-6394a90a406a","label":"FDA DailyMed — Fluconazole tablets, Dosage and Administration and Warnings (NuCare Pharmaceuticals), SPL effective 17 Nov 2025; via the openFDA drug label API","quote":"vaginal candidiasis is 150 mg as a single oral dose … Doses up to 400 mg/day may be used … Absolute doses exceeding 600 mg/day are not recommended … rare cases of serious hepatic toxicity, including fatalities.","accessed":"2026-08-27"},{"id":"fda_fluconazole_safety","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=01df20c4-7b94-044e-e063-6394a90a406a","label":"FDA DailyMed — Fluconazole tablets, Contraindications and Precautions/Drug Interactions (NuCare Pharmaceuticals), SPL effective 17 Nov 2025","quote":"Coadministration of other drugs known to prolong the QT interval … such as erythromycin, pimozide, and quinidine are contraindicated … Prothrombin time may be increased … coumarin-type anticoagulants … hypoglycemia … glyburide … myopathy and rhabdomyolysis … atorvastatin and simvastatin.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}