{"ok":true,"entry":{"slug":"fenofibrate","kind":"medication","name":"fenofibrate","aliases":["Lipanthyl"],"brands_sg":["Lipanthyl","Fenosup Lidose","Fenogal Lidose","AA-Feno Micro","Trolip"],"class":"fibrate","tags":["heart-bp"],"use_for":"prescribed to lower triglycerides and ldl cholesterol","use_after":"healthhub: with or after food for most formulations","use_duration":null,"take_with":"food · healthhub: lipanthyl penta 145 with or without","pros":["healthhub: raises hdl while lowering ldl and fat","fda: one 160 mg tablet a day at the stated maximum","healthhub: may reduce risk of heart attack and stroke"],"cons":["fda: serious liver injury reported; enzymes monitored","fda: muscle damage risk rises alongside a statin","fda: more cholesterol into bile — gallstone risk"],"dose_note":"the us fda label for the fenofibrate tablet gives an initial 160 mg once daily for primary hypercholesterolaemia or mixed dyslipidaemia and 54 to 160 mg once daily for severe hypertriglyceridaemia, stating 'the maximum dose is 160 mg once daily' and calling 160 mg 'the maximum recommended dose'; in mild to moderate renal impairment the same label starts at 54 mg per day. singapore registers a wider spread of strengths across different formulations — 100, 145, 160, 200 and 300 mg capsules and tablets, plus choline fenofibrate 45 mg and 135 mg — and these formulations are not interchangeable milligram for milligram. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["healthhub: liver, kidney or gallbladder problems","fda: contraindicated in severe renal impairment or dialysis","healthhub: past pancreatitis or an underactive thyroid","fda: contraindicated in active liver disease and nursing mothers"],"clashes":[{"src":["fda_feno_di","hh_feno_food"],"note":"fda: prolongation of pt/inr observed; healthhub also lists warfarin","with":"warfarin and other coumarin anticoagulants"},{"src":["fda_feno_warn","hh_feno_food"],"note":"fda: myopathy and rhabdomyolysis risk increases when co-administered with a statin","with":"statins (e.g. simvastatin, atorvastatin)"},{"src":["fda_feno_di","hh_feno_food"],"note":"fda: combined nephrotoxicity risk may lead to deterioration of renal function","with":"cyclosporine, tacrolimus"},{"src":["fda_feno_di","hh_feno_howto"],"note":"fda: resins bind other drugs; healthhub separates the doses by hours","with":"cholestyramine, colestipol (bile acid resins)"},{"src":["fda_feno_di"],"note":"fda: myopathy including rhabdomyolysis reported with fenofibrate plus colchicine","with":"colchicine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 15 rows containing fenofibrate read Forensicclassification 'Prescription Only' — Lipanthyl Penta 145mg and Supra 160mg, Fenosup Lidose 160mg, Fenogal Lidose 200mg, AA-Feno Micro 200mg, Trolip 100/300mg, Trolate 100/300mg, Tricor 160mg, EP-Feno 145mg; ATC C10AB05.","accessed":"2026-08-27"},{"id":"hh_feno_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fenofibrate","label":"HealthHub (Pharmaceutical Society of Singapore) — Fenofibrate: what is this medication for","quote":"They lower the amount of 'fat' (triglyceride) and 'bad cholesterol' … as well as increase … 'good cholesterol' … fibrates may reduce your risk for heart attack and stroke.","accessed":"2026-08-27"},{"id":"hh_feno_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fenofibrate","label":"HealthHub — Fenofibrate: how should I take this medication","quote":"This medicine should be taken with or after food. However, for special formulations of fenofibrate (e.g. Lipanthyl Penta 145, Trilipix 135, Trilipix 45), you may take this medication with or without food … Swallow the tablet/capsule whole.","accessed":"2026-08-27"},{"id":"hh_feno_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fenofibrate","label":"HealthHub — Fenofibrate: what precautions should I take","quote":"You have liver, kidney or gallbladder problems. You have an underactive thyroid gland. You have had a history of pancreatitis … You are pregnant, planning to become pregnant, or breastfeeding.","accessed":"2026-08-27"},{"id":"hh_feno_food","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/fenofibrate","label":"HealthHub — Fenofibrate: what food or medication should I avoid","quote":"Medications for cholesterol-lowering (e.g. cholestyramine, colestipol, statins, ezetimibe); Medications used to suppress immune system (e.g. cyclosporine, tacrolimus); Warfarin, a type of blood-thinner","accessed":"2026-08-27"},{"id":"fda_feno_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22fenofibrate%22&limit=5","label":"US FDA label — fenofibrate tablets, section 2 Dosage and Administration, via openFDA drug/label.json","quote":"Primary hypercholesterolemia or mixed dyslipidemia: Initial dose of 160 mg once daily. Severe hypertriglyceridemia: Initial dose of 54 to 160 mg once daily. Maximum dose is 160 mg … Should be given with meals.","accessed":"2026-08-27"},{"id":"fda_feno_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22fenofibrate%22&limit=5","label":"US FDA label — fenofibrate tablets, section 4 Contraindications, via openFDA drug/label.json","quote":"Severe renal dysfunction, including dialysis patients. Active liver disease. Gallbladder disease. Known hypersensitivity to fenofibrate. Nursing mothers.","accessed":"2026-08-27"},{"id":"fda_feno_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22fenofibrate%22&limit=5","label":"US FDA label — fenofibrate tablets, section 5 Warnings and Precautions, via openFDA drug/label.json","quote":"Hepatotoxicity: Serious drug-induced liver injury, including liver transplantation and death, has been reported … Myopathy and rhabdomyolysis … Risks are increased during co-administration with a statin … Cholelithiasis: Fenofibrate increases cholesterol excretion into the bile","accessed":"2026-08-27"},{"id":"fda_feno_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22fenofibrate%22&limit=5","label":"US FDA label — fenofibrate tablets, section 7 Drug Interactions, via openFDA drug/label.json","quote":"Potentiation of coumarin-type anticoagulant effects has been observed with prolongation of the PT/INR … Immunosuppressants such as cyclosporine and tacrolimus can produce nephrotoxicity … Cases of myopathy, including rhabdomyolysis, have been reported with fenofibrates co administered with colchicine","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}