{"ok":true,"entry":{"slug":"fadogia-agrestis","kind":"supplement","name":"fadogia agrestis","aliases":["fadogia"],"brands_sg":["EVLution Nutrition","Nutricost","Toniiq","ALLMAX","Vitamatic"],"class":"botanical","tags":["mens-health","fitness"],"use_for":"rat sexual-behaviour and testosterone studies only","use_after":null,"use_duration":null,"take_with":null,"pros":["rat studies report higher serum testosterone","the same rat study reports more frequent mating"],"cons":["no human trial appears in the sources read","28 days at 50–100 mg/kg harmed rat testes","sg bars sexual-dysfunction claims (table 6)"],"dose_note":"the evidence read here is in rats, not people: male albino rats were dosed at 18, 50 and 100 mg/kg body weight a day, with sexual behaviour and serum testosterone measured on days 1, 3 and 5, and a separate 28-day study used the same three doses; the 2014 review of virility plants lists fadogia agrestis only in its table of plant studies, with the stem extract's alkaloids and saponins credited with raising blood testosterone; nothing in these sources states a human dose, and no rda, ul, fda daily value or hsa singapore daily limit exists for fadogia agrestis","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["28 days at 50 and 100 mg/kg altered rat testicular function; the rats recovered mainly at the 18 mg/kg folklore dose","the sources read here contain no human safety study, so nothing is known about doses people actually take","not listed in hsa's prohibited or restricted annexes — that is absence of a listing, not a safety finding"],"clashes":[],"sources":[{"id":"yakubu2005","url":"https://europepmc.org/abstract/MED/16281088","label":"Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats (Yakubu et al., Asian Journal of Andrology 2005) — abstract via Europe PMC","quote":"Male rats were orally dosed with 18 mg/kg, 50 mg/kg and 100 mg/kg body weight … There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence","accessed":"2026-08-27"},{"id":"yakubu2008","url":"https://europepmc.org/abstract/MED/18023305","label":"Effects of oral administration of aqueous extract of Fadogia agrestis stem on some testicular function indices of male rats (Yakubu et al., Journal of Ethnopharmacology 2008) — abstract via Europe PMC","quote":"The alterations brought about by the aqueous extract of Fadogia agrestis stem are indications of adverse effects on the male rat testicular function and this may adversely affect the functional capacities of the testes.","accessed":"2026-08-27"},{"id":"sexualplants2014","url":"https://europepmc.org/article/PMC/PMC4151601","label":"A review on plants used for improvement of sexual performance and virility (Chauhan et al., BioMed Research International 2014) — Table 2 row 32","quote":"Fadogia agrestis Schweinf. Ex Hiern (Rubiaceae) Stem Alkaloids and Saponins Increased the blood testosterone concentrations","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — fadogia agrestis is NOT LISTED in either annex; Annex A runs 46. Excoecaria agallocha then 47. Folic acid where a 'Fadogia' row would fall","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical rows)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_claims_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (diseases/conditions not allowed for health supplements), reproductive-system row","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose … Reproductive system: Menstrual disorders, sexual dysfunction, infertility, frigidity, impotency, conception, pregnancy","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/fadogia-agrestis","label":"iHerb Singapore — Fadogia Agrestis category page, default listing order","quote":"1 - 11 of 11 results: EVLution Nutrition, Tongkat Ali + Fadogia Agrestis; EVLution Nutrition, Fadogia Agrestis 600 mg; Nutricost, Fadogia Agrestis 600 mg; Toniiq, Tongkat Ali + Fadogia; ALLMAX, Essentials Fadogia Agrestis 325 mg; Vitamatic, Fadogia Agrestis","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}