{"ok":true,"entry":{"slug":"eyebright","kind":"supplement","name":"eyebright","aliases":["Euphrasia officinalis"],"brands_sg":["Nature's Way","Nature's Answer","Christopher's Original Formulas","Swanson Vitamins"],"class":"botanical","tags":["general"],"use_for":"the human studies are eye drops, not oral capsules","use_after":null,"use_duration":null,"take_with":null,"pros":["84 preterm babies: a placebo-controlled eye-drop rct","65-patient cohort: 81.5% complete recovery reported","no serious adverse events in either eye-drop study"],"cons":["the rct missed its endpoint: 55.0% vs 51.2% placebo","the cohort was open-label with no control arm","no oral eyebright trial was found at all"],"dose_note":"both fetched human studies used topical eye drops, not an oral supplement. the randomised placebo-controlled trial gave one drop in each eye four times a day for 96 hours in preterm neonates with ocular discharge, and the open cohort prescribed one drop one to five times a day, describing one drop three times a day as the general prescribed dosage. no dose for swallowed eyebright was found in any fetched source. no rda, ul or fda daily value exists for eyebright, and hsa's tables 4–5 cover vitamins and minerals only, so no sg daily maximum applies","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["oral eyebright capsules and tinctures carry no fetched human evidence — both trials used eye drops","the randomised trial was in preterm neonates, a population that does not transfer to adults","singapore: not listed in hsa annex a or b, which is not a safety clearance"],"clashes":[],"sources":[{"id":"meiergirard2020","url":"https://europepmc.org/article/MED/32850558","label":"Euphrasia Eye Drops in Preterm Neonates With Ocular Discharge: A Randomized Double-Blind Placebo-Controlled Trial (Meier-Girard D et al.; Front Pediatr 2020; PMID 32850558)","quote":"Euphrasia or placebo was administrated at a dose of one drop in each eye four times a day over a period of 96 h … 22 (55.0%) achieved our primary outcome compared to 21 (51.2%) in the placebo arm","accessed":"2026-08-27"},{"id":"stoss2000","url":"https://europepmc.org/article/MED/11152054","label":"Prospective cohort trial of Euphrasia single-dose eye drops in conjunctivitis (Stoss M, Michels C, Peter E, Beutke R, Gorter RW; J Altern Complement Med 2000; PMID 11152054)","quote":"A complete recovery was seen in 53 patients (81.5%) … No serious adverse events were observed … A dosage of one drop three times a day seems to be the general prescribed dosage.","accessed":"2026-08-27"},{"id":"hsa_hs_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines (January 2026), Table 6: Examples of Diseases/Conditions/Disorders Not Allowed for Health Supplements","quote":"Eyes and ears — Blindness, cataract, deafness … Others — Cancers, infectious diseases, inflammatory conditions or diseases","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025), Annex A (118 rows, Abrus to Zinc) and Annex B (4 rows) — both searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines (January 2026), clause 4.8 and Tables 4–5 (vitamins and minerals only)","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/eyebright","label":"iHerb Singapore — Eyebright category page, default order (1 - 7 of 7 results); the 7 listings carry only 4 distinct brands: Nature's Way, Nature's Answer, Christopher's Original Formulas, Swanson Vitamins","quote":"Nature's Way, Eyebright Herb, 100 Vegan Capsules … Nature's Answer, Eyebright Herb, Fluid Extract, Alcohol-Free … Christopher's Original Formulas, Herbal Eye Formula … Swanson Vitamins, Bilberry Eyebright Vision Complex","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:19.87501+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}