{"ok":true,"entry":{"slug":"ergothioneine","kind":"supplement","name":"ergothioneine","aliases":["L-ergothioneine","EGT"],"brands_sg":["California Gold Nutrition","Life Extension","Toniiq","ProHealth Longevity","Real Mushrooms"],"class":"amino acid","tags":["general","cognitive"],"use_for":"mushroom-derived antioxidant · evidence is associational","use_after":null,"use_duration":null,"take_with":"food · mushrooms are the richest dietary source","pros":["efsa judged 30 mg/day in adults safe as a supplement","mushrooms are the richest dietary source"],"cons":["human data is associational, not trial-based","efsa's dose excludes pregnancy and breastfeeding","hsa's numeric limits cover vitamins/minerals only"],"dose_note":"efsa assessed a food-supplement dose of up to 30 mg a day for adults (20 mg/day for ages 3–17), excluding pregnant and breastfeeding women","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["pregnancy or breastfeeding — outside efsa's supplement dose","not on hsa's prohibited/restricted lists — which are not exhaustive"],"clashes":[],"sources":[{"id":"efsa2017","url":"https://europepmc.org/article/PMC/PMC7010164","label":"EFSA NDA Panel — Statement on the safety of synthetic l-ergothioneine as a novel food (EFSA Journal 2017)","quote":"recommended daily dose of up to 30 mg/day for adults excluding pregnant and breastfeeding women and 20 mg/day for children from 3–17 years … The Panel concludes that synthetic l-ergothioneine is safe under the proposed uses and use levels","accessed":"2026-08-27"},{"id":"cheah2021","url":"https://europepmc.org/article/PMC/PMC8113028","label":"Ergothioneine, recent developments (Cheah & Halliwell, Redox Biology 2021)","quote":"the highest dietary levels of ET are found in certain mushrooms … lower blood levels of ET have been associated with incidence of several disorders including Parkinson disease (PD), mild cognitive impairment (MCI), Crohn's disease (CD) and frailty","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/l-ergothioneine","label":"iHerb Singapore — L-Ergothioneine category page","quote":"L-Ergothioneine: Mushroom Antioxidant Capsules | iHerb","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Real Mushrooms","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}