{"ok":true,"entry":{"slug":"eleuthero","kind":"supplement","name":"eleuthero","aliases":["Siberian ginseng","Eleutherococcus senticosus"],"brands_sg":["California Gold Nutrition","NOW Foods","Imperial Elixir","Swanson Vitamins","Nature's Answer"],"class":"botanical","tags":["energy"],"use_for":"fatigue and weakness — an ema traditional-use approval","use_after":null,"use_duration":"one 8-week study used 120 mg a day of root extract","take_with":null,"pros":["ema approved it for symptoms of asthenia in 2014","a who monograph cites less exhaustion and tiredness"],"cons":["approval rests on long use, not trial evidence","trials are heterogeneous and low quality","products vary; one case traced to a toxic substitute"],"dose_note":"one 8-week randomised study used 120 mg a day of root extract in people with stress-related asthenia","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["high blood pressure — it rose in some people who had it","product identity varies — one case was traced to periploca sepium","not listed in hsa's annexes — that is not a safety clearance"],"clashes":[],"sources":[{"id":"eleuthero2025","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12605232/","label":"Eleutherococcus root: phytochemistry and pharmacological potential as an adaptogen (Front Pharmacol 2025)","quote":"The European Medicines Agency (EMA) approved E. senticosus root in 2014 for the treatment of symptoms of asthenia … classified as a traditional herbal medicine entirely based on its long-standing use … the lack of robust clinical evidence","accessed":"2026-08-27"},{"id":"eleuthero2025_safety","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12605232/","label":"Eleutherococcus root — clinical dose, blood pressure and product-identity findings (Front Pharmacol 2025)","quote":"compare the effect of 120 mg/day of E. senticosus root extract … an increase in blood pressure was also observed in some people with hypertension … a case of neonatal androgenization associated with maternal eleuthero use","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025, GL-CHPB-1-012)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026, GL-CHPB-3-001 Rev. 020), Tables 4–5","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/eleuthero","label":"iHerb Singapore — category listing (default order)","quote":"Eleuthero","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}