{"ok":true,"entry":{"slug":"dutasteride","kind":"medication","name":"dutasteride","aliases":["Avodart","Duodart"],"brands_sg":["Avodart","Duodart","Dutaster","Dutasvitae","Intasteride"],"class":"5-alpha reductase inhibitor","tags":["hormonal"],"use_for":"prescribed for an enlarged prostate (bph), men only","use_after":"healthhub: once a day, with or without food","use_duration":null,"take_with":"water · healthhub: swallowed whole, not chewed or opened","pros":["healthhub: lowers dht and shrinks the prostate","fda label: one 0.5 mg capsule once daily","healthhub: used alone or with tamsulosin"],"cons":["healthhub: erection problems, lower libido","healthhub: may take 6 months or more to notice","fda: may raise the risk of high-grade prostate cancer"],"dose_note":"the us fda label for dutasteride states 'The recommended dose of dutasteride is 1 capsule (0.5 mg) taken once daily' and, in combination, '0.5 mg once daily and tamsulosin 0.4 mg once daily' — 0.5 mg once daily is the whole adult label range, with no higher step. every dutasteride product on the sg register is 0.5 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnancy — fda: contraindicated in women who are pregnant","women who are or may be pregnant should not handle the capsules (healthhub, fda)","blood donation — healthhub: not during, or for 6 months after, treatment","heart or liver problems (healthhub)"],"clashes":[{"src":["fda_duta_di"],"note":"fda: use caution — potential for drug-drug interactions; the effect has not been studied","with":"ritonavir and other potent chronic cyp3a4 inhibitors"},{"src":["fda_duta_di"],"note":"fda: decrease dutasteride clearance and raise exposure; no dose adjustment is recommended","with":"verapamil or diltiazem"},{"src":["fda_duta_ae"],"note":"fda: ejaculation disorders occurred in 11% on combination vs 2% on dutasteride alone","with":"tamsulosin (combination therapy)"},{"src":["fda_duta_warn"],"note":"fda: dutasteride reduces serum psa by about 50%, so a new psa baseline is needed","with":"psa blood testing"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached locally at /tmp/hsa_all.json and filtered locally)","quote":"All 11 registered dutasteride products carry Forensicclassification 'Prescription Only' — SIN12434P AVODART SOFT CAPSULE 0.5 mg · SIN14181P Duodart Capsules 0.5mg/0.4mg · SIN15882P DUTASTER · SIN15590P DUTASVITAE · SIN15563P INTASTERIDE","accessed":"2026-08-27"},{"id":"hh_duta_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dutasteride","label":"HealthHub (Pharmaceutical Society of Singapore) — Dutasteride: what is this medication for","quote":"It lowers dihydrotestosterone, and thus shrinks the prostate and relieves the symptoms. Therefore, this medication is for use in men only. It may take up to 6 months or more for you to notice an effect.","accessed":"2026-08-27"},{"id":"hh_duta_admin","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dutasteride","label":"HealthHub — Dutasteride: how should I take or use this medication","quote":"You may take this medication with or without food. This medication should be swallowed whole; do not chew or open as contact with the contents of the capsules may make your mouth or throat sore.","accessed":"2026-08-27"},{"id":"hh_duta_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dutasteride","label":"HealthHub — Dutasteride: what precautions should I take","quote":"Avoid donating blood during treatment or for 6 months after you stopped the treatment … Inform your healthcare professional if: You are allergic to this medication … You have heart or liver problem","accessed":"2026-08-27"},{"id":"hh_duta_se","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/dutasteride","label":"HealthHub — Dutasteride: common side effects","quote":"Unable to get or keep an erection firm enough to have sexual intercourse; Decreased libido (sex drive); Difficulty with ejaculation; Dizziness when taken in combination with tamsulosin","accessed":"2026-08-27"},{"id":"fda_duta_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22DUTASTERIDE%22&limit=3","label":"US FDA label for dutasteride capsules, section 2 Dosage and Administration, via openFDA drug/label.json (effective 2026-08-14)","quote":"The recommended dose of dutasteride is 1 capsule (0.5 mg) taken once daily … Combination with tamsulosin: 0.5 mg once daily and tamsulosin 0.4 mg once daily … May take with or without food.","accessed":"2026-08-27"},{"id":"fda_duta_ci","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22DUTASTERIDE%22&limit=3","label":"US FDA label for dutasteride capsules, section 4 Contraindications, via openFDA","quote":"Dutasteride use is contraindicated in women who are pregnant … dutasteride may cause fetal harm when administered to a pregnant woman … clinically significant hypersensitivity … to dutasteride or other 5 alpha-reductase inhibitors","accessed":"2026-08-27"},{"id":"fda_duta_warn","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22DUTASTERIDE%22&limit=3","label":"US FDA label for dutasteride capsules, section 5 Warnings and Precautions, via openFDA","quote":"Dutasteride reduces serum prostate-specific antigen (PSA) concentration by approximately 50% … Dutasteride may increase the risk of high-grade prostate cancer … Patients should not donate blood until 6 months after their last dose","accessed":"2026-08-27"},{"id":"fda_duta_di","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22DUTASTERIDE%22&limit=3","label":"US FDA label for dutasteride capsules, section 7 Drug Interactions, via openFDA","quote":"Use with caution in patients taking potent, chronic cytochrome P450 (CYP)3A4 enzyme inhibitors (e.g., ritonavir) … Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride.","accessed":"2026-08-27"},{"id":"fda_duta_ae","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22DUTASTERIDE%22&limit=3","label":"US FDA label for dutasteride capsules, section 6 Adverse Reactions, via openFDA","quote":"Ejaculation disorders occurred significantly more in subjects receiving combination therapy (11%) compared with those receiving dutasteride (2%) or tamsulosin (4%) as monotherapy.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}