{"ok":true,"entry":{"slug":"doxycycline","kind":"medication","name":"doxycycline","aliases":["doxycycline hyclate","doxycycline hydrochloride","doxycycline monohydrate"],"brands_sg":["Doxyline","Microdox","Medomycin","Apo-Doxy","Doxycap","Doxymycin"],"class":"antibiotic (tetracycline)","tags":["antibiotic","skin"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"full glass of water · upright 30 min · same time each day","use_duration":null,"take_with":"food · dairy/antacids/minerals: 2 h before or 1 h after","pros":["once or twice a day per nhs","with or after food — easier on the stomach"],"cons":["sun sensitivity — burns more easily","headaches, nausea or vomiting are common (nhs)","nhs: best to skip alcohol — can stop it working"],"dose_note":"as prescribed by your doctor; healthhub/nhs: complete the course even if you feel better; nhs: most people take it once or twice a day","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["pregnant or breastfeeding — not usually used (baby's teeth)","children: not usual under 12 (nhs) · under 8 (sg leaflet, us label)","tetracycline allergy · lupus · myasthenia gravis · liver or kidney condition","sun sensitivity — sunblock and long sleeves per sg leaflet; us label: treatment discontinued at first skin redness"],"clashes":[{"src":["hh_doxycycline","fda_doxycycline","nhs_doxycycline"],"note":"absorption impaired (us label) · sg leaflet: at least 2 h before or 1 h after doxycycline","with":"calcium, iron, zinc, magnesium, antacids, bismuth, aluminium"},{"src":["hh_doxycycline","fda_doxycycline"],"food":true,"note":"sg leaflet: not at the same time (same 2 h / 1 h gap) · us label: absorption not markedly cut by milk","with":"milk and dairy"},{"src":["fda_doxycycline","nhs_doxycycline"],"note":"tetracyclines depress prothrombin activity — anticoagulant dose may need lowering","with":"warfarin / anticoagulants"},{"src":["hh_doxycycline","fda_doxycycline","nhs_doxycycline"],"note":"raised pressure in the head (sg leaflet) · us label: avoid isotretinoin with doxycycline","with":"isotretinoin, acitretin (acne / psoriasis retinoids)"},{"src":["hh_doxycycline","fda_doxycycline"],"note":"sg leaflet: may not work as well — use another method during the course · us label: may be less effective","with":"oral contraceptives"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (official open dataset on data.gov.sg, last updated 7 Aug 2026; same register as HSA Infosearch)","quote":"Forensicclassification = 'Prescription Only' for all 7 registered doxycycline products (all oral) — SIN10340P DOXYLINE CAPSULE 100 mg · SIN08388P DOXYLINE ENTERIC COATED CAPSULE 100 mg · SIN08536P MICRODOX CAPSULE 100 mg · SIN00968P MEDOMYCIN CAPSULE 100 mg · SIN08445P APO-DOXY-TABS 100 mg · SIN08101P DOXYCAP CAPSULE U.S.P. 100 mg · SIN02205P DOXYMYCIN-100 CAPSULES 100 mg — all 'Prescription Only'","accessed":"2026-08-27"},{"id":"hh_doxycycline","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/doxycycline","label":"HealthHub (MOH Singapore / Pharmaceutical Society of Singapore) — Doxycycline medication information leaflet, reviewed 26 May 2026","quote":"Doxycycline is an antibiotic commonly used to treat bacterial infections … This medicine should be taken with or after food. Swallow this medication with a full glass of water and sit or stand upright for at least 30 minutes to prevent stomach and throat irritation. You should complete each course of antibiotics even if you feel better … Inform your healthcare professional if: … You are pregnant, planning to become pregnant, or breastfeeding. The patient is a child under 8 years' old … Systemic lupus erythematosus … Myasthenia gravis … Kidney or liver problems … This medicine may cause your skin to be more sensitive to the sun, hence you may get sunburn more easily. Apply sunblock, wear long-sleeved clothing, and avoid direct sunlight … Avoid taking Doxycycline at the same time with milk or dairy products, or indigestion medicines such as antacids or medicines containing bismuth, iron, zinc, magnesium, aluminium or calcium. These should be taken at least 2 hours before or 1 hour after Doxycycline. Inform your doctor if you are taking Isotretinoin (a medicine used to treat acne) or Acitretin (a medicine used to treat psoriasis). Taking Doxycycline together with these medicines may increase the risk of high pressure in the head leading to headaches, nausea and vomiting. Birth control pills may not work as well to prevent pregnancy if taken together with Doxycycline. Use other forms of birth control while on this medicine.","accessed":"2026-08-27"},{"id":"nhs_doxycycline","url":"https://www.nhs.uk/medicines/doxycycline/","label":"NHS Medicines A-Z — Doxycycline (single consolidated page, reviewed 5 September 2025)","quote":"Doxycycline is an antibiotic medicine used to treat or prevent certain infections. It's only available with a prescription … Most people need to take it once or twice a day for a few days or weeks … try to take it at the same time each day … swallow tablets or capsules whole with a glass of water while sitting or standing up … avoid lying down for at least 30 minutes after taking it (this helps stop the medicine irritating your throat) … It's important to keep taking your medicine until you've finished it all, even if you start to feel better … Most adults and children aged 12 years or over can take doxycycline. It's not usually given to younger children because it can affect how their teeth develop … it may not be suitable if: you've had an allergic reaction to doxycycline or another antibiotic · you have a liver or kidney condition · you have lupus or myasthenia gravis · you have problems with alcohol dependence · you're pregnant or breastfeeding … [common side effects] headaches, feeling sick (nausea) and being sick (vomiting), a rash … your skin being more sensitive to the sun … [may not mix well:] anticoagulants (such as warfarin) · antacids and other indigestion treatments · acne medicines · medicines or supplements that contain iron or zinc … You can eat as normal while taking doxycycline, but it's best not to drink alcohol because it can stop the medicine working properly.","accessed":"2026-08-27"},{"id":"fda_doxycycline","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b8b76aaa-575b-497f-b854-c42bc992c784","label":"FDA DailyMed — Doxycycline Hyclate Tablets, USP (Strides Pharma Science Ltd) prescribing information, label effective 26 Jun 2026, SPL v3","quote":"Rx only … This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines … The use of drugs of the tetracycline class during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown) … Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some individuals taking tetracyclines … treatment should be discontinued at the first evidence of skin erythema … Concomitant use of isotretinoin and doxycycline hyclate should be avoided because isotretinoin is also known to cause pseudotumor cerebri … patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage … Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations. Absorption of tetracyclines is impaired by bismuth subsalicylate. Barbiturates, carbamazepine, phenytoin, and rifampin shorten the half-life of doxycycline … Concurrent use of tetracycline may render oral contraceptives less effective … Administration of adequate amounts of fluid along with capsule and tablet forms of drugs in the tetracycline class is recommended to wash down the drugs and reduce the risk of esophageal irritation and ulceration … If gastric irritation occurs, it is recommended that doxycycline be given with food or milk. The absorption of doxycycline is not markedly influenced by simultaneous ingestion of food or milk … Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}