{"ok":true,"entry":{"slug":"dmae","kind":"supplement","name":"DMAE","aliases":["dimethylaminoethanol","deanol"],"brands_sg":["NOW Foods","Source Naturals","Force Factor","Vitacost","Life Extension"],"class":"specialty compound","tags":["cognitive"],"use_for":"marketed for focus — a choline precursor, evidence is thin","use_after":null,"use_duration":null,"take_with":null,"pros":["acts as a choline precursor for acetylcholine","not named in HSA's prohibited or restricted annexes"],"cons":["'suggested' 500–2000 mg rests on old, weak data","reviews flag uncertainty about real cognitive gains","no RDA, no upper limit, no SG cap set"],"dose_note":"a 2025 narrative review reports suggested daily intakes of 500–2000 mg for deanol (DMAE); it reports the range rather than endorsing it","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["cognitive claims trace to a narrative review, not trials","not covered by HSA's supplement limit tables"],"clashes":[],"sources":[{"id":"nootropics2025","url":"https://europepmc.org/article/PMC/PMC12466949","label":"Focus on Cognitive Enhancement: A Narrative Overview of Nootropics and \"Smart Drug\" Use and Misuse (Biology 2025)","quote":"deanol (DMAE) and meclofenoxate serve as choline precursors, supporting acetylcholine synthesis and potentially improving learning and memory, with suggested daily intakes ranging from 500 to 2000 mg","accessed":"2026-08-27"},{"id":"nootropics2025b","url":"https://europepmc.org/article/PMC/PMC12466949","label":"Focus on Cognitive Enhancement: A Narrative Overview of Nootropics and \"Smart Drug\" Use and Misuse (Biology 2025) — abstract","quote":"there are relevant levels of uncertainty in terms of smart drugs' effectiveness in improving executive functions","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A","quote":"Annex A: List of substances which are prohibited or restricted for use with … [neither DMAE, deanol nor dimethylaminoethanol appears in Annex A or Annex B]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 4: Vitamins Limits … Table 5: Minerals Limits [neither table names DMAE or deanol]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/dmae","label":"iHerb Singapore — dmae category page (default best-selling order)","quote":"NOW Foods · Source Naturals · Force Factor · Vitacost · Life Extension [first distinct brands, default order]","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Force Factor","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":6}],"updated_at":"2026-08-30T17:59:39.960259+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}