{"ok":true,"entry":{"slug":"diosmectite","kind":"medication","name":"diosmectite","aliases":["Smecta","smectite"],"brands_sg":["Smecta"],"class":"adsorbent antidiarrhoeal","tags":["digestive"],"use_for":"acute diarrhoea in adults and children from 2 years","use_after":"label: an average of 3 sachets a day, for 7 days","use_duration":null,"take_with":"50 ml water · preferably in between meals","pros":["general sale list in sg — no prescription needed","cochrane: may cut diarrhoea by about a day in children","cochrane: no deaths or serious adverse effects reported"],"cons":["cochrane rates the evidence low-certainty","no effect on hospitalisation or iv fluid need","binds other medicines — healthhub: 2 h apart"],"dose_note":"sg smecta 3 g sachet label (national drug formulary): adults, “an average of 3 sachets per day for 7 days”, contents “thoroughly stirred in 50 ml of water”; children over 2 years, “2 to 3 sachets per day”; “in case of acute diarrhoea, the daily dosage can be doubled” at the start; the label sets no separate ceiling beyond that and says to consult a doctor if symptoms do not improve within 7 days — as directed on the label or by your pharmacist","dosage":null,"ul_status":null,"sg_class":"general-sale","cautions":["fructose intolerance, glucose and galactose malabsorption, sucrase deficiency — sg label: contraindicated","under 2 years — the sg label covers children from 2 years upward only","symptoms persisting or worsening after 1 week — healthhub: speak to your healthcare professional","fluid and electrolyte depletion may occur in people with diarrhoea — sg label"],"clashes":[{"src":["healthhub_antidiarrhoeal"],"note":"healthhub: adsorbents may reduce absorption — two hours apart","with":"other medicines taken by mouth"}],"sources":[{"id":"ndf_smecta","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin06338p/","label":"Singapore National Drug Formulary — SMECTA SACHET 3 G/SACHET [SIN06338P] product information, indication + forensic classification, last updated 28 July 2026","quote":"Treatment of acute diarrhoea in children of 2 years and above, in addition to oral rehydration. Treatment of acute diarrhoea in adults … Fluid and electrolyte depletion may occur in patients who have diarrhoea … Forensic Classification GENERAL SALE LIST","accessed":"2026-08-27"},{"id":"ndf_smecta_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin06338p/","label":"Singapore National Drug Formulary — SMECTA SACHET 3 G/SACHET [SIN06338P], Dosing section","quote":"Adults: An average of 3 sachets per day for 7 days. The contents should be thoroughly stirred in 50 ml of water … Children … Over the age of 2 years: 2 to 3 sachets per day … preferably in between meals","accessed":"2026-08-27"},{"id":"ndf_smecta_warn","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin06338p/","label":"Singapore National Drug Formulary — SMECTA SACHET 3 G/SACHET [SIN06338P], Dosing + Contraindications / Special Warnings","quote":"In case of acute diarrhoea, the daily dosage can be doubled … If the symptoms do not improve within 7 days, consult your doctor … contraindicated in patients with a fructose intolerance, glucose and galactose malabsorption syndrome or sucrase/somaltase deficiency","accessed":"2026-08-27"},{"id":"healthhub_antidiarrhoeal","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/anti-diarrhoeal","label":"HealthHub (MOH Singapore) — Anti-Diarrhoeal, medication information leaflet (lists dioctahedral smectite), article last reviewed 23 January 2024","quote":"Dioctahedral smectite … work by binding to the toxins … may reduce the absorption of other medications. They must be taken apart from other medications by two hours … If your symptoms persist or worsen after 1 week … speak to your healthcare professional","accessed":"2026-08-27"},{"id":"cochrane_smectite2018","url":"https://europepmc.org/article/MED/29693719","label":"Cochrane Database of Systematic Reviews — Smectite for acute infectious diarrhoea in children (Pérez-Gaxiola et al., 2018, issue 4; 18 trials, 2616 children), PMID 29693719 / PMC6494641","quote":"Smectite may reduce the duration of diarrhoea by approximately a day … low-certainty evidence … There was no evidence of an effect on need for hospitalization … and need for intravenous rehydration … No deaths or serious adverse effects were reported","accessed":"2026-08-27"},{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084, managed by Health Sciences Authority, last updated 7 Aug 2026), Forensicclassification column","quote":"SMECTA SACHET 3 g/sachet | SIN06338P | General Sale List | DIOCTAHEDRAL SMECTITE | 3g/sachet | DKSH SINGAPORE PTE. LTD. — the only smectite product in the register; no row matches the spelling 'diosmectite' (pulled via datastore_search API, 27 Aug 2026)","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:18.585742+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}