{"ok":true,"entry":{"slug":"damiana","kind":"supplement","name":"damiana","aliases":["Turnera diffusa"],"brands_sg":["Swanson Vitamins","Nature's Way","Nature's Answer","Solaray","Oregon's Wild Harvest"],"class":"botanical","tags":["mens-health"],"use_for":"traditional aphrodisiac — human data is a 3-herb blend","use_after":null,"use_duration":null,"take_with":null,"pros":["no human psychiatric or neurological reports found","centuries of traditional use as a stimulant"],"cons":["not among the 8 ed ingredients with rct evidence","the one human trial tested a 3-herb blend, not damiana","sg bars sexual-dysfunction and obesity claims"],"dose_note":"the human evidence read here does not test damiana on its own: the 2001 trial used 'YGD' capsules combining yerba maté, guarana and damiana, three capsules before each main meal, and reported 5.1 kg of weight loss over 45 days against 0.3 kg on placebo — an effect the paper attributes to delayed gastric emptying and cannot separate between the three herbs; the 2023 erectile-dysfunction review catalogues Turnera diffusa among its 41 ingredients but not among the eight with clinical evidence of efficacy; no rda, ul, fda daily value or hsa singapore daily limit exists for damiana","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the 2020 review found no psychiatric or neurological side-effect reports for damiana — that is absence of reports, not evidence of safety","the only human trial read here combined damiana with two caffeine-bearing herbs, yerba maté and guarana","not listed in hsa's prohibited or restricted annexes — that is absence of a listing, not a safety finding"],"clashes":[],"sources":[{"id":"enhancers2020_damiana","url":"https://europepmc.org/article/PMC/PMC7602496","label":"Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects (Cinquina et al., Pharmaceuticals 2020) — discussion of Turnera diffusa","quote":"damiana (Turnera diffusa Willd. Ex. Schult.) … has been traditionally used for centuries as a stimulant and aphrodisiac, to spark male sexual drive and increase performance, and is still widely marketed","accessed":"2026-08-27"},{"id":"enhancers2020_damiana_ae","url":"https://europepmc.org/article/PMC/PMC7602496","label":"Cinquina et al., Pharmaceuticals 2020 — adverse-effect search result for Turnera diffusa (source's own spelling 'damania' preserved)","quote":"No relevant reports were found for A. Mexicana, E. longifolia, L. meyenii, T. diffusa, V. africana, and W. somnifera … no psychiatric or neurological side effects related to damania were reported.","accessed":"2026-08-27"},{"id":"ygd2001_composition","url":"https://europepmc.org/abstract/MED/11424516","label":"Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients (Andersen & Fogh, Journal of Human Nutrition and Dietetics 2001) — abstract via Europe PMC","quote":"One such mixed herbal preparation is 'YGD' containing Yerbe Maté (leaves of Ilex paraguayenis), Guarana (seeds of Paullinia cupana) and Damiana (leaves of Turnera diffusa var. aphrodisiaca).","accessed":"2026-08-27"},{"id":"ygd2001_result","url":"https://europepmc.org/abstract/MED/11424516","label":"Andersen & Fogh, Journal of Human Nutrition and Dietetics 2001 — results and dosing of the YGD combination","quote":"three capsules of YGD capsules before each main meal for 45 days … Body weight reductions were … 5.1 +/- 0.5 kg after PGD capsules compared to 0.3 +/- 0.08 kg after placebo over 45 days","accessed":"2026-08-27"},{"id":"ed_review2023_noeff","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use (Barbonetti et al., Nutrients 2023) — results","quote":"A total of 41 different active ingredients were used by manufacturers … Based on the literature analysis, we found that 33 out of the 41 ingredients had no reported efficacy on ED.","accessed":"2026-08-27"},{"id":"ed_review2023_eight","url":"https://europepmc.org/article/PMC/PMC10490034","label":"Barbonetti et al., Nutrients 2023 — the eight ingredients with recognised clinical evidence of efficacy (Turnera diffusa is catalogued in Table 1 but is not among these eight)","quote":"six EIs with evidence of efficacy were supported by at least two RCTs, namely, Eurycoma longifolia, Panax ginseng, L-arginine, Corynanthe yohimbe, Tribulus terrestris and Pinus pinaster. The remaining two EIs, namely, Crocus sativus and Withania somnifera","accessed":"2026-08-27"},{"id":"hsa_prohibited","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (October 2025), Annex A (118 rows) and Annex B (4 rows) — damiana / Turnera diffusa is NOT LISTED in either annex; Annex A runs 36. Croton tiglium then 37. Danthron, and 103. Symphytum asperum then 104. Urginea maritima, where 'Damiana' and 'Turnera' rows would fall","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 with Tables 4–5 (vitamins and minerals only — no botanical rows)","quote":"4.8 HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_claims_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 6.6 and Table 6 (diseases/conditions not allowed for health supplements), reproductive-system row","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose … Reproductive system: Menstrual disorders, sexual dysfunction, infertility, frigidity, impotency, conception, pregnancy","accessed":"2026-08-27"},{"id":"hsa_claims_table6_metabolic","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), Table 6, metabolic-system row","quote":"Metabolic system Obesity, gout","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/damiana","label":"iHerb Singapore — Damiana category page, default listing order","quote":"1 - 7 of 7 results: Swanson Vitamins, Full Spectrum Damiana 510 mg; Nature's Way, Damiana Leaves; Nature's Answer, Damiana Extract Alcohol-Free; Solaray, True Herbs Damiana 370 mg; Nature's Answer, Damiana; Oregon's Wild Harvest, Damiana","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}