{"ok":true,"entry":{"slug":"colostrum","kind":"supplement","name":"colostrum","aliases":["bovine colostrum","IgG colostrum"],"brands_sg":["California Gold Nutrition","Mt. Capra","Nutricost","NOW Foods","Symbiotics"],"class":"dairy derivative","tags":["immune","gut"],"use_for":"gut permeability in athletes · immune markers barely move","use_after":"no timing rule given","use_duration":null,"take_with":null,"pros":["review: reversed exercise-raised gut permeability","review notes fewer upper-airway illnesses in sportsmen","not on the HSA prohibited or restricted lists"],"cons":["10-trial meta-analysis: little change in IgA and IgG","child data conflict; little evidence in older adults","milk-derived — a dairy product by definition"],"dose_note":"no dose is given: the immunological meta-analysis reports no consensus on a supplementation strategy and the gut-permeability review calls for studies to determine the optimal dose schedule","dosage":{"ul":null,"unit":null,"fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["cow's-milk allergy or dairy intolerance — colostrum is a mammalian milk secretion","most trials are in trained athletes, not in general adults","little evidence is available on its use with older adults, and results in children conflict"],"clashes":[],"sources":[{"id":"col_syst","url":"https://europepmc.org/article/PMC/PMC8308243","label":"Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review (Nutrients, 2021) — abstract via Europe PMC REST, PMC8308243","quote":"Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen … Conflicting results were provided in pediatric population and little evidence is available on its use with older adults","accessed":"2026-08-27"},{"id":"col_syst_def","url":"https://europepmc.org/article/PMC/PMC8308243","label":"Bovine Colostrum Applications in Sick and Healthy People: A Systematic Review (Nutrients, 2021) — abstract via Europe PMC REST, PMC8308243 — opening definition","quote":"Colostrum is the first secretion of mammalian glands during the early period after birth giving. Its components are biologically active … Bovine colostrum has the highest concentration of these substances","accessed":"2026-08-27"},{"id":"col_immuno","url":"https://europepmc.org/article/PMC/PMC7231218","label":"Immunological Outcomes of Bovine Colostrum Supplementation in Trained and Physically Active People: A Systematic Review and Meta-Analysis (Nutrients, 2020) — abstract via Europe PMC REST, PMC7231218","quote":"BC supplementation has no or a fairly low impact on improving the concentration of serum immunoglobulins (IgA, IgG), lymphocytes and neutrophils, and saliva immunoglobulin (IgA) in athletes … there is no consensus on the supplementation strategy","accessed":"2026-08-27"},{"id":"col_gut","url":"https://europepmc.org/article/PMC/PMC9227274","label":"A Systematic Review of the Influence of Bovine Colostrum Supplementation on Leaky Gut Syndrome in Athletes: Diagnostic Biomarkers and Future Directions (Nutrients, 2022) — abstract via Europe PMC REST, PMC9227274","quote":"Nine studies were selected … vigorous exercise profoundly increases intestinal permeability, and BC supplementation helps to reverse gut permeability in athletes … well-designed, placebo-controlled, and randomized studies are needed","accessed":"2026-08-27"},{"id":"hsa_hs_guidelines","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines GL-CHPB-3-001 Rev. No. 020 (January 2026), clause 4.8 (Tables 4–5 list vitamins and minerals only; no colostrum row)","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5","accessed":"2026-08-27"},{"id":"hsa_prohibited_2025","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Singapore — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3; Annexes A and B checked","quote":"highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [colostrum, bovine-derived ingredients, milk and immunoglobulin are not listed in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/colostrum","label":"iHerb Singapore — “Colostrum: Bovine Grass-Fed Powder & IgG Capsules” category page, default order, 77 results","quote":"California Gold Nutrition, Colostrum … Mt. Capra, Goat Colostrum … Nutricost, Colostrum … NOW Foods, Colostrum … Symbiotics, Colostrum Plus®","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}