{"ok":true,"entry":{"slug":"colchicine","kind":"medication","name":"colchicine","aliases":["Colcrys"],"brands_sg":["Colcitex","Colchicine Halewood","Xoline"],"class":"anti-gout agent","tags":["pain-fever"],"use_for":"healthhub: treatment and prevention of gout flares","use_after":"healthhub: once gout flare symptoms start · short courses","use_duration":null,"take_with":"healthhub: with or after food · nhs: swallowed whole, water","pros":["nhs: it reduces gout pain and joint inflammation","nhs: also prevents attacks when gout treatment starts","sg register: 0.5 mg and 0.6 mg tablets registered"],"cons":["nhs: doses too close together can build up and harm","healthhub: stomach pain, diarrhoea, nausea, vomiting","nhs: rare bone-marrow, nerve, muscle and kidney harm"],"dose_note":"no singapore package insert was read. the us label for colchicine tablets states \"The maximum recommended dose for prophylaxis of gout flares is 1.2 mg/day\" and \"The maximum recommended dose for treatment of gout flares is 1.8 mg over a 1-hour period\", with 1.2 mg to 2.4 mg daily for familial mediterranean fever. those figures are for 0.6 mg tablets; two of the three sg-registered products are 0.5 mg tablets. nhs quotes no figure and warns that doses taken closer together than prescribed can build up. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["a blood condition (nhs) or blood disorder (healthhub)","kidney problems or dialysis (nhs + healthhub)","liver or heart problems (nhs)","stomach ulcer, crohn's, colitis or coeliac disease (nhs)"],"clashes":[{"src":["hh_col_avoid","nhs_col_mix"],"food":true,"note":"healthhub: it may increase the risk of side effects; nhs: it can be dangerous","with":"grapefruit and grapefruit juice"},{"src":["nhs_col_mix"],"note":"nhs lists them among medicines that may not mix well with colchicine","with":"statins"},{"src":["nhs_col_mix"],"note":"nhs lists these antibiotics among medicines that may not mix well","with":"erythromycin or clarithromycin"},{"src":["nhs_col_mix"],"note":"nhs lists these heart medicines among those that may not mix well","with":"verapamil, diltiazem or digoxin"},{"src":["nhs_col_mix"],"note":"nhs lists hiv medicines and post-transplant ciclosporin among those that may not mix well","with":"ritonavir and ciclosporin"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 3 colchicine rows, 27 Aug 2026","quote":"COLCITEX TABLET 0.6 mg SIN12301P · COLCHICINE HALEWOOD TABLET 500 MCG SIN15572P · XOLINE TABLET 500MCG SIN17275P — ATC M04AC01, all tablets; all 3 rows read Forensicclassification \"Prescription Only\"","accessed":"2026-08-27"},{"id":"nhs_col_about","url":"https://www.nhs.uk/medicines/colchicine/","label":"NHS medicines A–Z — Colchicine: what colchicine is for and how to take it (reviewed 20 August 2026)","quote":"Colchicine treats gout by reducing pain and joint inflammation. It's used for a short time to: relieve symptoms of a gout attack; prevent attacks … Colchicine comes as tablets, which you swallow whole with a glass of water.","accessed":"2026-08-27"},{"id":"nhs_col_howto","url":"https://www.nhs.uk/medicines/colchicine/","label":"NHS medicines A–Z — Colchicine: important information on dosing","quote":"When taking colchicine, do not take your doses closer together than your doctor has told you. This can cause too much of the medicine to build up in your body, which can cause serious side effects.","accessed":"2026-08-27"},{"id":"nhs_col_side","url":"https://www.nhs.uk/medicines/colchicine/","label":"NHS medicines A–Z — Colchicine: side effects","quote":"too much of the medicine building up in your body (toxicity) …; bone marrow problems …; nerve problems (neuropathy) …; muscle and kidney problems – causing symptoms such as muscle pain, muscle weakness, and dark red or brown pee","accessed":"2026-08-27"},{"id":"nhs_col_who","url":"https://www.nhs.uk/medicines/colchicine/","label":"NHS medicines A–Z — Colchicine: who can and cannot take colchicine","quote":"you have a blood condition; you have kidney problems or are having dialysis; you have a condition that affects your digestive system, such as a stomach ulcer, Crohn's disease, ulcerative colitis or coeliac disease; you have liver or heart problems","accessed":"2026-08-27"},{"id":"nhs_col_mix","url":"https://www.nhs.uk/medicines/colchicine/","label":"NHS medicines A–Z — Colchicine: taking colchicine with other medicines, food and drink","quote":"statins …; some types of antibiotic, such as erythromycin and clarithromycin; some types of heart medicine, such as verapamil, diltiazem and digoxin; ritonavir; cimetidine; ciclosporin … Do not drink grapefruit juice","accessed":"2026-08-27"},{"id":"hh_col_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/colchicine","label":"HealthHub (Pharmaceutical Society of Singapore / MOH) — Colchicine: what is this medication for (leaflet reviewed 25 March 2025)","quote":"Colchicine is used for the treatment and prevention of gout flares. Gout is a condition that can cause pain and swelling in the joints. Gout happens when there is too much uric acid in the blood.","accessed":"2026-08-27"},{"id":"hh_col_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/colchicine","label":"HealthHub — Colchicine: how should I take or use this medication","quote":"Take this medication once you get the symptoms of a gout flare … Colchicine can be taken with or after food. Do not take more doses than what your doctor recommends.","accessed":"2026-08-27"},{"id":"hh_col_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/colchicine","label":"HealthHub — Colchicine: what are some common side effects of this medication","quote":"Stomach pain or cramp; Loose stools or diarrhoea … Nausea or vomiting … Take the medication with or after food to reduce nausea","accessed":"2026-08-27"},{"id":"hh_col_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/colchicine","label":"HealthHub — Colchicine: what precautions should I take","quote":"You have a history of Liver condition; Kidney condition; Blood disorder; You are pregnant, planning to become pregnant, or breastfeeding","accessed":"2026-08-27"},{"id":"hh_col_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/colchicine","label":"HealthHub — Colchicine: what food or medication should I avoid","quote":"Avoid taking grapefruit or grapefruit juice while you are taking Colchicine as grapefruit may interact with Colchicine and increase the risk of side-effects.","accessed":"2026-08-27"},{"id":"fda_col_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:%22colchicine%22&limit=5","label":"US label for colchicine tablets 0.6 mg (Proficient Rx, effective 2025-07-01) via openFDA drug/label.json, Dosage and Administration","quote":"The maximum recommended dose for prophylaxis of gout flares is 1.2 mg/day. … The maximum recommended dose for treatment of gout flares is 1.8 mg over a 1-hour period. … FMF in adults is 1.2 mg to 2.4 mg daily.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}