{"ok":true,"entry":{"slug":"co-trimoxazole","kind":"medication","name":"co-trimoxazole","aliases":["sulfamethoxazole + trimethoprim","Bactrim","Septrin"],"brands_sg":["Apo-Sulfatrim","Suprim","Mortin","Trimaxazole","Co-Trimexazole"],"class":"sulfonamide antibiotic combination","tags":["antibiotic"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"healthhub: the whole course, even once you feel better","use_duration":null,"take_with":"healthhub: with or without food · a meal eases nausea","pros":["healthhub: two antibiotics blocking two growth steps","fda: one ds tablet every 12 hours for most adult uses","sg register: tablets, paediatric tablets, suspension"],"cons":["fda: nausea, vomiting, appetite loss and rash lead","fda: rare fatal skin, blood, liver and lung reactions","healthhub: sun sensitivity; thrush can follow a course"],"dose_note":"the us bactrim label states 'The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 10 to 14 days', and for paediatric prophylaxis sets an explicit ceiling — 'The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim'; higher weight-based regimens (75–100 mg/kg sulfamethoxazole a day) exist for pneumocystis pneumonia only; no sg label with a dosing section was found; as directed on the label or by your doctor","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["sulfa allergy, or rash after a sulfa drug — healthhub says tell your professional","g6pd deficiency — fda label: haemolysis may occur, often dose-related","pregnancy — fda warns of a possible rise in birth defects","kidney or liver problems, folate deficiency, asthma — fda says avoid"],"clashes":[{"src":["fda_bactrim","healthhub_cotrim"],"note":"fda: prothrombin time may lengthen — the label says monitor pt and inr","with":"warfarin"},{"src":["fda_bactrim","healthhub_cotrim"],"note":"fda: phenytoin half-life rose 39% — the label says monitor levels","with":"phenytoin"},{"src":["fda_bactrim","healthhub_cotrim"],"note":"fda: avoid concurrent use — free methotrexate levels can rise","with":"methotrexate"},{"src":["healthhub_cotrim","fda_bactrim"],"note":"healthhub: these raise potassium, as co-trimoxazole can","with":"ace inhibitors, arbs, spironolactone"},{"src":["fda_bactrim"],"note":"fda: avoid concurrent use — more thrombocytopenia with purpura reported","with":"thiazide diuretics in older people"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (open dataset on data.gov.sg; same register as HSA Infosearch)","quote":"Forensicclassification = 'Prescription Only' for all 10 sulphamethoxazole+trimethoprim products: SIN00435P APO-SULFATRIM, SIN00508P APO-SULFATRIM PEDIATRIC, SIN02308P SUPRIM B.P. 480, SIN01417P SUPRIM SUSPENSION, SIN10251P MORTIN, SIN10250P MORTIN-DS, SIN00407P TRIMAXAZOLE, SIN00583P CO-TRIMEXAZOLE, SIN00960P B.S., SIN02183P DBL injection.","accessed":"2026-08-27"},{"id":"ndf_apo_sulfatrim","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00435p/","label":"MOH National Drug Formulary — APO-SULFATRIM TABLET [SIN00435P], SG product information (last updated 28 July 2026)","quote":"SULPHAMETHOXAZOLE - 400 MG TRIMETHOPRIM - 80 MG … Forensic Classification: PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription: NA","accessed":"2026-08-27"},{"id":"healthhub_cotrim","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/co-trimoxazole","label":"HealthHub (MOH Singapore / Pharmaceutical Society of Singapore) — Co-trimoxazole medication information leaflet (reviewed 20 Oct 2021)","quote":"an antibiotic made up of two different antibiotics … blocking two essential steps in the growth of bacteria … may be taken with or without food … more sensitive to the sun … may cause a fungal infection called thrush.","accessed":"2026-08-27"},{"id":"fda_bactrim","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22BACTRIM%22&limit=1","label":"FDA / openFDA drug label — BACTRIM and BACTRIM DS (sulfamethoxazole and trimethoprim) tablets, prescribing information (Sun Pharmaceutical, effective 30 Dec 2024)","quote":"The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours … The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}