{"ok":true,"entry":{"slug":"cloxacillin","kind":"medication","name":"cloxacillin","aliases":["Orbenin"],"brands_sg":["Cloxacap","Oxacil","Cloxacillin Panpharma","Meixam"],"class":"penicillinase-resistant penicillin","tags":["antibiotic"],"use_for":"prescribed for staph and other bacterial infections","use_after":"every six hours · half to one hour before food (sg)","use_duration":null,"take_with":"water, on an empty stomach · 2 h apart from probiotics","pros":["holds up against penicillinase-producing staph","capsules and granules both registered in sg","oral form used as follow-up after injections"],"cons":["penicillin allergy can be serious — labels warn","diarrhoea, nausea and bloating are common (sg)","not for initial treatment of severe infections"],"dose_note":"the singapore cloxacap 500 insert (SIN08889P) gives the adult figure as \"Oral, 250 to 500 mg every six hours; or as directed\" — 500 mg every six hours is the top of the label's stated adult range, and the insert sets no separate daily ceiling. for children it lists \"Oral 12.5 to 25 mg per kg of body weight every six hours\" up to 20 kg, with children 20 kg and over on the adult dose. the same insert notes cloxacillin \"should not be used orally for the initial treatment of severe life-threatening infections\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["past reaction to penicillins, cephalosporins or beta-lactams","kidney problems — sg leaflet: tell your doctor","persistent or bloody diarrhoea — sg leaflet: seek advice","other medicines, supplements or herbal remedies — flag them"],"clashes":[{"src":["hh_clox_avoid"],"note":"sg leaflet: 2 h apart — the antibiotic may reduce the probiotic's effect","with":"probiotics"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for cloxacillin)","quote":"Forensicclassification = 'Prescription Only' for all 5 cloxacillin rows: SIN05036P CLOXACAP 250 CAPSULE; SIN08889P CLOXACAP 500 CAPSULE; SIN09934P OXACIL GRANULES 125MG/5ML; SIN07168P CLOXACILLIN PANPHARMA FOR INJECTION; SIN15834P MEIXAM POWDER FOR SOLUTION FOR INJECTION","accessed":"2026-08-27"},{"id":"ndf_cloxacap_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08889p/","label":"MOH National Drug Formulary — CLOXACAP 500 CAPSULE 500 MG [SIN08889P], product information","quote":"CLOXACILLIN SODIUM EQV CLOXACILLIN - 500 MG … Dosage Form CAPSULE … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_cloxacap_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08889p/","label":"MOH National Drug Formulary — CLOXACAP 500 [SIN08889P], indications","quote":"For treatment of: Infections caused by penicillinase-producing staphylococci … Respiratory tract infections … Skin and soft-tissue infections … Disseminated infections caused by pneumococci, group A beta-hemolytic streptococci","accessed":"2026-08-27"},{"id":"ndf_cloxacap_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08889p/","label":"MOH National Drug Formulary — CLOXACAP 500 [SIN08889P], dosage and administration","quote":"Adult dose Oral, 250 to 500 mg every six hours; or as directed. Paediatric dose … Oral 12.5 to 25 mg per kg of body weight every six hours; or as directed.","accessed":"2026-08-27"},{"id":"ndf_cloxacap_note","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08889p/","label":"MOH National Drug Formulary — CLOXACAP 500 [SIN08889P], dosage note","quote":"Cloxacillin should not be used orally for the initial treatment of severe life-threatening infections, but may be used as a follow-up therapy after parenteral penicillinase-resistant penicillin therapy.","accessed":"2026-08-27"},{"id":"ndf_cloxacap_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08889p/","label":"MOH National Drug Formulary — CLOXACAP 500 [SIN08889P], contraindications","quote":"Avoid in patients known to be hypersensitive to penicillins.","accessed":"2026-08-27"},{"id":"hh_clox_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub (National Medication Information workgroup / Pharmaceutical Society of Singapore) — Cloxacillin medication information leaflet","quote":"Cloxacillin belongs to a group of antibiotics known as penicillin, and is used to treat bacterial infections. It works by stopping the growth of bacteria.","accessed":"2026-08-27"},{"id":"hh_clox_how","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub — Cloxacillin: how should I take or use this medication","quote":"Take this medication half to one hour before food. You should complete each course of antibiotics even if you feel better as incomplete treatment might cause the infection to return or cause antibiotic resistance.","accessed":"2026-08-27"},{"id":"hh_clox_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub — Cloxacillin: what precautions should I take","quote":"Inform your healthcare professional if: You had a previous allergic reaction to Cloxacillin, Amoxicillin, Penicillins, Cephalexin, Cefuroxime or other beta lactam antibiotics … You have kidney problems.","accessed":"2026-08-27"},{"id":"hh_clox_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub — Cloxacillin: common side effects","quote":"Some common side effects include: Diarrhoea Nausea, vomiting Stomach upset or discomfort Bloating … you may develop a black, \"hairy\" tongue while taking this medication. This effect is harmless","accessed":"2026-08-27"},{"id":"hh_clox_serious","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub — Cloxacillin: rare but serious side effects","quote":"Persistent diarrhoea, abdominal or stomach pain/cramp, blood/mucus in your stool This could suggest a severe intestinal condition (pseudomembranous colitis). This condition may occur during the course of this medication or weeks after","accessed":"2026-08-27"},{"id":"hh_clox_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/cloxacillin","label":"HealthHub — Cloxacillin: what food or medication should I avoid","quote":"Take this medication 2 hours apart from probiotics as the antibiotics may reduce the effectiveness of probiotics.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:16.693643+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}