{"ok":true,"entry":{"slug":"ciclosporin","kind":"medication","name":"ciclosporin","aliases":["cyclosporine","Neoral","Sandimmun"],"brands_sg":["Sandimmun Neoral","Sandimmun","Deximune","Strineora","Ikervis"],"class":"calcineurin-inhibitor immunosuppressant","tags":["other"],"use_for":"healthhub: psoriasis, eczema, lupus, transplant rejection","use_after":"healthhub: usually twice daily, kept steady with meals","use_duration":null,"take_with":"healthhub: capsules swallowed whole with a glass of water","pros":["healthhub: tunes down an over-aggressive immune attack","sg label: also covers uveitis, ra, psoriasis, eczema","register: capsules, oral solution and eye drops in sg"],"cons":["healthhub: raises kidney markers and blood pressure","healthhub: gum overgrowth, tremor, extra body hair","healthhub: infection risk rises while taking it"],"dose_note":"dosing is by body weight and set by the prescriber. the singapore product information for sandimmun neoral (national drug formulary) states “Except in patients with refractory cases of sight-threatening endogenous uveitis and in children with nephrotic syndrome, the total daily dose must never exceed 5 mg/kg.” — 5 mg/kg a day is the label ceiling for the usual indications. the same sg label starts psoriasis at “2.5 mg/kg per day orally given in 2 divided doses” and says any increase “should not exceed 5 mg/kg”, and caps atopic dermatitis cycles at “a maximum of 8 weeks”. healthhub says the doctor works the dose out from body weight and condition.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["cancer, kidney problems or high blood pressure (healthhub)","uncontrolled hypertension or uncontrolled infection — sg label contraindications","pregnant, planning pregnancy or breastfeeding — healthhub asks that this be declared","signs of infection such as fever or sore throat — healthhub asks for prompt advice"],"clashes":[{"src":["hh_cic_avoid"],"food":true,"note":"healthhub asks that these be avoided during ciclosporin treatment","with":"grapefruit, pomelo, pineapple and starfruit"},{"src":["hh_cic_avoid"],"note":"healthhub: these are avoided; flu and pneumococcal vaccines are safe","with":"live vaccines (polio, yellow fever, mmr, typhoid, bcg)"},{"src":["hh_cic_avoid"],"note":"healthhub: check with the doctor or pharmacist first, including otc","with":"other medicines, supplements and herbal remedies"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg d_767279312753558cbf19d48344577084); all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (not re-fetched), 12 ciclosporin/cyclosporine rows","quote":"SANDIMMUN NEORAL CAPSULE 100 mg SIN08177P · SANDIMMUN CONCENTRATE FOR INFUSION SIN00520P · DEXIMUNE CAPSULES 25MG SIN14047P · STRINEORA 100 SIN17521P · IKERVIS EYE DROPS SIN15216P — all 12 rows read Forensicclassification “Prescription Only” (ATC L04AD01, S01XA18)","accessed":"2026-08-27"},{"id":"hh_cic_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ciclosporin","label":"HealthHub (Pharmaceutical Society of Singapore / MOH) — Ciclosporin: what is this medication for","quote":"Ciclosporin is used in conditions such as Systemic Lupus Erythematosus, psoriasis and eczema and to prevent rejection of transplanted organs. It “tames” your immune system and in turn, tunes down the aggressiveness of its attack","accessed":"2026-08-27"},{"id":"hh_cic_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ciclosporin","label":"HealthHub — Ciclosporin: how should I take or use this medication","quote":"It is given orally, consistent with relation to time of day and meals. Ciclosporin is usually given twice daily … Swallow your capsules with a glass of water. Do not break or crush them","accessed":"2026-08-27"},{"id":"hh_cic_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ciclosporin","label":"HealthHub — Ciclosporin: what precautions should I take","quote":"If you have cancer, kidney problems, or high blood pressure … Seek prompt advice from your doctor when you develop any symptoms of infection e.g. fever, sore throat, yellow/green phlegm, urinary tract infection","accessed":"2026-08-27"},{"id":"hh_cic_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ciclosporin","label":"HealthHub — Ciclosporin: common side effects","quote":"More than 10% of people will experience: Increase in kidney marker; High blood pressure; Headache including migraine; Tremor … Inflammation/overgrowth of gums … Hair overgrowth in male-like pattern","accessed":"2026-08-27"},{"id":"hh_cic_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/ciclosporin","label":"HealthHub — Ciclosporin: what food or medication should I avoid","quote":"Avoid taking grapefruits, pomelo, pineapple, or starfruit during treatment with Ciclosporin. You should avoid live vaccines such as live polio, yellow fever, rubella (German measles), MMR … Flu and pneumococcal vaccines are safe","accessed":"2026-08-27"},{"id":"ndf_cic_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08177p/","label":"Singapore National Drug Formulary — SANDIMMUN NEORAL CAPSULE 100 mg [SIN08177P], Dosage and Administration","quote":"Except in patients with refractory cases of sight-threatening endogenous uveitis and in children with nephrotic syndrome, the total daily dose must never exceed 5 mg/kg.","accessed":"2026-08-27"},{"id":"ndf_cic_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08177p/","label":"Singapore National Drug Formulary — SANDIMMUN NEORAL [SIN08177P], Indications and psoriasis dosing","quote":"the recommended initial dose is 2.5 mg/kg per day orally given in 2 divided doses. If there is no improvement after 1 month, the daily dose may be gradually increased, but should not exceed 5 mg/kg","accessed":"2026-08-27"},{"id":"ndf_cic_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin08177p/","label":"Singapore National Drug Formulary — SANDIMMUN NEORAL [SIN08177P], Contraindications (non-transplant indications)","quote":"Uncontrolled hypertension; Uncontrolled infection; History of known or diagnosed malignancy of any kind except premalignant or malignant skin changes.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}