{"ok":true,"entry":{"slug":"chaga","kind":"supplement","name":"chaga","aliases":["Inonotus obliquus"],"brands_sg":["California Gold Nutrition","Swanson Vitamins","Nutricost","Real Mushrooms","Host Defense"],"class":"mushroom","tags":["immune"],"use_for":"limited human evidence — mostly polysaccharide lab research","use_after":null,"use_duration":null,"take_with":null,"pros":["a 2026 review groups it with immune mushrooms","widely studied as a source of polysaccharides","named among the most studied medicinal mushrooms"],"cons":["case report: oxalate kidney injury at 10-15 g a day","that case needed dialysis and high-dose steroids","human efficacy data is thin — reviews are lab-based"],"dose_note":"no dose is established for chaga; the only human report sourced here is a case of acute oxalate nephropathy in a 69-year-old man who took 10-15 g of chaga powder a day alongside 500 mg of vitamin c for three months, and the paper attributes it to excessive ingestion","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["kidney disease or a history of kidney stones — a case report ties chaga powder at 10-15 g a day to acute oxalate nephropathy with calcium oxalate crystals in the tubules","large or long-running doses — the case report names excessive ingestion of chaga as the reported cause","the sourced benefit claims are polysaccharide activities from lab work, not outcomes measured in people","not listed in hsa's annex a/b — hsa says that list is not exhaustive"],"clashes":[{"src":["chaga_oxalate2022"],"note":"in the published oxalate-nephropathy case the chaga powder was taken together with 500 mg of vitamin c a day for three months; the report does not separate the two","with":"high-dose vitamin c"}],"sources":[{"id":"chaga_oxalate2022","url":"https://europepmc.org/article/PMC/PMC8913114","label":"Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report (Medicine 2022) — exposure","quote":"A 69-year-old man who ingested Chaga mushroom powder (10-15 g per day) and vitamin C (500 mg per day) for the past 3 months developed acute kidney injury (AKI)","accessed":"2026-08-27"},{"id":"chaga_oxalate2022_mech","url":"https://europepmc.org/article/PMC/PMC8913114","label":"Chaga oxalate nephropathy case report, Medicine 2022 — reported mechanism","quote":"recent studies have reported that excessive ingestion of Chaga mushrooms can cause acute oxalate nephropathy … the deposition of calcium oxalate crystals in the tubules","accessed":"2026-08-27"},{"id":"chaga_oxalate2022_outcome","url":"https://europepmc.org/article/PMC/PMC8913114","label":"Chaga oxalate nephropathy case report, Medicine 2022 — treatment required","quote":"we recommended hemodialysis and the administration of a high dose of steroids (intravenous hydrocortisone 500 mg twice a day for 3 days and oral prednisolone at 1 mg/kg)","accessed":"2026-08-27"},{"id":"iop2026","url":"https://europepmc.org/article/PMC/PMC13075156","label":"Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications (Nutrients 2026)","quote":"this review summarizes its isolation and purification methods, structural characteristics, structure-activity relationships, biological properties and mechanisms, as well as their potential applications","accessed":"2026-08-27"},{"id":"mush2026_species","url":"https://europepmc.org/article/PMC/PMC13209540","label":"Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential (Molecules 2026) — species in scope","quote":"Among the most widely studied and utilized species are Ganoderma lucidum, Lentinula edodes, Grifola frondosa, Cordyceps militaris, Cordyceps sinensis, Trametes versicolor, and Inonotus obliquus.","accessed":"2026-08-27"},{"id":"mush2026_clinical","url":"https://europepmc.org/article/PMC/PMC13209540","label":"Medicinal Mushrooms and Their Bioactive Compounds, Molecules 2026 — what the clinical literature shows","quote":"Experimental and clinical studies indicate that extracts derived from these species may support immune function, modulate inflammatory responses, and exhibit antioxidant, antimicrobial, and anticancer properties.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/chaga","label":"iHerb Singapore — Chaga category (default order, 32 results); first 5 distinct brands: California Gold Nutrition, Swanson Vitamins, Nutricost, Real Mushrooms, Host Defense","quote":"California Gold Nutrition, Fungiology, MushRex Plus … Swanson Vitamins, Full Spectrum® Chaga Mushroom, 400 mg … Nutricost, Organic Chaga Mushroom … Real Mushrooms, Chaga, Mushroom Extract Powder … Host Defense, Mushrooms™, Chaga","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Real Mushrooms","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}