{"ok":true,"entry":{"slug":"ceramides","kind":"supplement","name":"ceramides","aliases":["phytoceramides","rice ceramides","konjac ceramides"],"brands_sg":["Idealove","Dr. Althea","Vanicream","G9skin","Purito"],"class":"lipid","tags":["skin-hair"],"use_for":"skin barrier — lower water loss in one 12-week trial","use_after":"daily","use_duration":"the water-loss effect showed only at 12 weeks","take_with":null,"pros":["one randomised placebo-controlled trial supports it","no supplement-related adverse events in that trial"],"cons":["limited human evidence — one 30-person trial","tested only in healthy Japanese adults","12 weeks passed before water loss differed"],"dose_note":"the supporting trial ran 12 weeks in 30 healthy adults; no standard oral dose is established in that source","dosage":{"ul":null,"unit":null,"fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":[],"clashes":[],"sources":[{"id":"nutrients2024","url":"https://europepmc.org/article/PMC/PMC11243426","label":"Efficacy and Safety of Oral Administration of Wine Lees Extract (WLE)-Derived Ceramides and Glucosylceramides in Enhancing Skin Barrier Function (Nutrients 2024) — randomised, double-blind, placebo-controlled trial","quote":"A randomized, double-blind, placebo-controlled study was conducted with 30 healthy Japanese subjects … after 12 weeks of administration, the test group had significantly lower TEWL than the placebo (p = 0.04) … No adverse events related to the supplements were reported","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Guidelines on health supplements (Singapore), maximum daily limits Tables 4–5","quote":"Table 4: Vitamins Limits … Nutrient Maximum Daily Limit … Table 5: Minerals Limits","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/ceramides","label":"iHerb Singapore — Ceramides: Barrier Creams, Serums & Capsules category page (default best-selling order)","quote":"Ceramides: Barrier Creams, Serums & Capsules","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}