{"ok":true,"entry":{"slug":"cefuroxime","kind":"medication","name":"cefuroxime","aliases":["Zinnat"],"brands_sg":["Zinnat","Ceftil","Axetine","Shincef","Cefuroxime-AFT"],"class":"second-generation cephalosporin","tags":["antibiotic"],"use_for":"prescribed for bacterial infections — your doctor decides","use_after":"usually every 12 hours · sg course is often 5–10 days","use_duration":null,"take_with":"food · zinnat label: after food for optimum absorption","pros":["sg label: usual course seven days (five to ten)","tablets and a suspension are both registered in sg","us label lists a single-dose option for gonorrhoea"],"cons":["tablets cannot be crushed or split (sg label)","beta-lactam allergy can be serious — labels warn","diarrhoea and nausea/vomiting are the most common"],"dose_note":"the us cefuroxime axetil tablet label caps routine adult dosing at \"250 mg or 500 mg every 12 hours\" (adults and adolescents 13 years and older), with two higher one-off entries in the same table: \"Uncomplicated gonorrhea 1,000 mg single dose\" and \"Early Lyme disease 500 mg every 12 hours\" for 20 days. the singapore zinnat insert (SIN02364P) states \"The usual course of therapy is seven days (range five to ten days)\" and \"ZINNAT should be taken after food for optimum absorption\". as directed on the label or by your pharmacist/doctor.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["allergy to penicillins or cephalosporins — tell your doctor","kidney problems — sg label: dosage reduced","under 3 months — sg label: no experience of use","trouble swallowing whole tablets — suspension exists instead"],"clashes":[{"src":["fda_cefu_int"],"note":"us label: 1 h before or 2 h after short-acting antacids; h2 blockers and ppis avoided","with":"antacids and other acid-reducing medicines"},{"src":["fda_cefu_int"],"note":"us label: raises systemic exposure — coadministration not recommended","with":"probenecid"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset; filtered locally for cefuroxime)","quote":"Forensicclassification = 'Prescription Only' for all 12 cefuroxime rows (5 oral tablets, 1 oral suspension, 6 injections) — e.g. SIN02364P ZINNAT TABLET 500 mg; SIN12049P CEFTIL TABLET 250 mg; SIN07013P ZINNAT FOR SUSPENSION 125 mg/5 ml","accessed":"2026-08-27"},{"id":"ndf_zinnat_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], product information","quote":"CEFUROXIME AXETIL EQV CEFUROXIME - 500 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"ndf_zinnat_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], therapeutic indications","quote":"ZINNAT is an oral prodrug of the bactericidal cephalosporin antibiotic cefuroxime … Indications include: Upper respiratory tract infections … Lower respiratory tract infections … Genito-urinary tract infections … Skin and soft tissue infections.","accessed":"2026-08-27"},{"id":"ndf_zinnat_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], posology","quote":"The usual course of therapy is seven days (range five to ten days) … The duration of therapy should be determined by the type of infection and the response of the patient, and should generally not be longer than recommended.","accessed":"2026-08-27"},{"id":"ndf_zinnat_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], method of administration","quote":"Oral use. ZINNAT should be taken after food for optimum absorption.","accessed":"2026-08-27"},{"id":"ndf_zinnat_tablets","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], posology (tablet handling)","quote":"ZINNAT tablets should not be crushed or split and are therefore unsuitable for treatment of patients, such as younger children, who cannot swallow whole tablets.","accessed":"2026-08-27"},{"id":"ndf_zinnat_paed","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], paediatric use","quote":"When doses below 250 mg are required, ZINNAT FOR SUSPENSION 125mg/5ml should be used. There is no experience of using ZINNAT in children under the age of 3 months.","accessed":"2026-08-27"},{"id":"ndf_zinnat_renal","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin02364p/","label":"MOH National Drug Formulary — ZINNAT TABLET 500 MG [SIN02364P], dosage in renal impairment","quote":"In patients with markedly impaired renal function, it is recommended that the dosage of cefuroxime be reduced to compensate for its slower excretion","accessed":"2026-08-27"},{"id":"fda_cefu_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=119c4d09-2324-498f-9318-1f8db49ad4b6","label":"FDA DailyMed — Cefuroxime axetil tablets (A-S Medication Solutions), Dosage and Administration, eff. 2025-10-08","quote":"Adults and Adolescents (13 years and older) … Uncomplicated skin and skin-structure infections 250 mg or 500 mg every 12 hours … Uncomplicated gonorrhea 1,000 mg single dose Early Lyme disease 500 mg every 12 hours","accessed":"2026-08-27"},{"id":"fda_cefu_contra","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=119c4d09-2324-498f-9318-1f8db49ad4b6","label":"FDA DailyMed — Cefuroxime axetil tablets, Contraindications","quote":"contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil tablets or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins)","accessed":"2026-08-27"},{"id":"fda_cefu_int","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=119c4d09-2324-498f-9318-1f8db49ad4b6","label":"FDA DailyMed — Cefuroxime axetil tablets, Drug Interactions","quote":"Administer cefuroxime axetil at least 1 hour before or 2 hours after administration of short-acting antacids. Histamine-2 (H2) antagonists and proton pump inhibitors should be avoided … Coadministration with probenecid increases systemic exposure … not recommended.","accessed":"2026-08-27"},{"id":"fda_cefu_adverse","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=119c4d09-2324-498f-9318-1f8db49ad4b6","label":"FDA DailyMed — Cefuroxime axetil tablets, Adverse Reactions","quote":"The most common adverse reactions (≥3%) for cefuroxime axetil tablets are diarrhea, nausea/vomiting, Jarisch-Herxheimer reaction, and vaginitis (early Lyme disease).","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}