{"ok":true,"entry":{"slug":"casein-protein","kind":"supplement","name":"casein protein","aliases":["micellar casein","calcium caseinate"],"brands_sg":["California Gold Nutrition","Nutricost","NOW Foods","ALLMAX","Optimum Nutrition"],"class":"protein","tags":["fitness"],"use_for":"overnight muscle protein synthesis · daily protein total","use_after":"30–40 g in the half hour before sleep in issn's stand","use_duration":null,"take_with":"water or milk · slower to digest than whey","pros":["issn: 30–40 g pre-sleep raised overnight synthesis","amino acids released slowly through the night","9.3% leucine — behind whey, ahead of most proteins"],"cons":["slower mps response than whey at rest and after lifting","8 weeks of 54 g: morning vs evening made no difference","a milk protein — not an option with milk allergy"],"dose_note":"issn's stand describes 30–40 g of casein about 30 minutes before sleep; the bedtime drinks in the studies nih ods cites contained 27.5 or 40 g","dosage":{"ul":null,"unit":"g","fda_dv":"50 g (protein)","rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["milk allergy — casein is the main protein in milk","kidney disease — protein-restricted diets apply; ask your doctor first","not listed in hsa annex a or b (oct 2025) — not a clearance"],"clashes":[],"sources":[{"id":"ods_ex_casein_digest","url":"https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/","label":"NIH ODS — Exercise and Athletic Performance (HP), protein implications for use","quote":"Digestion of casein, the main complete protein in milk, is slower than that of whey, so the release of amino acids from casein into the blood is slower","accessed":"2026-08-27"},{"id":"ods_ex_casein_bedtime","url":"https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/","label":"NIH ODS — Exercise and Athletic Performance (HP), pre-sleep protein","quote":"Participants in these studies consumed a bedtime drink containing 27.5 or 40 g of the milk protein casein, which increased circulating amino acid levels throughout the night","accessed":"2026-08-27"},{"id":"ods_ex_protein_ul","url":"https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/","label":"NIH ODS — Dietary Supplements for Exercise and Athletic Performance (Health Professional), protein safety (updated 1 Apr 2024)","quote":"The Food and Nutrition Board has not set a UL for protein, noting that the risk of adverse effects from excess protein from food is very low","accessed":"2026-08-27"},{"id":"issn_casein_presleep","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5477153/fullTextXML","label":"ISSN position stand: protein and exercise (Jäger et al., JISSN 2017) — position statement on pre-sleep casein","quote":"Pre-sleep casein protein intake (30–40 g) provides increases in overnight MPS and metabolic rate without influencing lipolysis","accessed":"2026-08-27"},{"id":"issn_casein_leucine","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5477153/fullTextXML","label":"Jäger et al., JISSN 2017 — milk proteins section","quote":"Comparison of the quality of whey and casein reveal that these two proteins routinely contain the highest leucine content of all other protein sources at 11% and 9.3%, respectively","accessed":"2026-08-27"},{"id":"issn_casein_vs_whey","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5477153/fullTextXML","label":"Jäger et al., JISSN 2017 — Tang et al. comparison of whey, soy and micellar casein","quote":"These authors reported that the ability of soy to stimulate MPS was greater than casein, but less than whey, at rest and in response to an acute resistance exercise stimulus","accessed":"2026-08-27"},{"id":"issn_casein_timing","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5477153/fullTextXML","label":"Jäger et al., JISSN 2017 — Antonio et al. morning vs evening casein","quote":"The authors reported no differences in body composition or performance between the morning and evening casein supplementation groups","accessed":"2026-08-27"},{"id":"issn_kidney","url":"https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5477153/fullTextXML","label":"ISSN position stand: protein and exercise (Jäger et al., JISSN 2017) — safety section","quote":"people in renal failure benefit from protein-restricted diets, but extending this pathophysiology to otherwise healthy exercise-trained individuals who are not clinically compromised is inappropriate","accessed":"2026-08-27"},{"id":"fda_dv","url":"https://www.fda.gov/food/nutrition-facts-label/daily-value-nutrition-and-supplement-facts-labels","label":"FDA — Daily Value on the Nutrition and Supplement Facts Labels, Reference Guide: Daily Values for Nutrients (content current as of 03/05/2024)","quote":"DVs are the recommended amounts of nutrients to consume or not to exceed each day … Protein | 50g","accessed":"2026-08-27"},{"id":"hsa_restricted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev 001 (Oct 2025), Annexes A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/casein-protein","label":"iHerb Singapore — Casein Protein category page, default sort","quote":"Casein Protein: Slow-Release Powder for Recovery | iHerb … Casein Protein 1 - 31 of 31 results","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Optimum Nutrition","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":2}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}