{"ok":true,"entry":{"slug":"carbamazepine","kind":"medication","name":"carbamazepine","aliases":["Tegretol"],"brands_sg":["Tegretol","Tegretol CR","Apo-Carbamazepine","Storilat"],"class":"anticonvulsant","tags":["other"],"use_for":"sg label: epilepsy, bipolar disorder, nerve pain in the face","use_after":"healthhub: after food helps · full effect can take weeks","use_duration":null,"take_with":"sg label: a little liquid, during or after meals","pros":["sg label: used alone or alongside other epilepsy drugs","healthhub: cr tablets release the drug slowly","sg label: trigeminal neuralgia is on the label too"],"cons":["healthhub: hsa requires hla-b*1502 testing in asians","nhs: rash and mouth ulcers can mean stevens-johnson","healthhub: it can make hormonal contraception fail"],"dose_note":"the singapore package insert for tegretol 200 tablet (SIN00352P) describes adult epilepsy dosing as \"Initially, 100 to 200 mg once or twice daily; the dosage should be slowly raised until … an optimum response is obtained. In some patients 1,600 mg or even 2,000 mg daily may be appropriate\", while capping the liquid: \"However, the maximum daily dose of oral suspension is limited to 1,200 mg\". for trigeminal neuralgia the same insert states \"Maximum recommended dose is 1,200 mg/day\", and for patients \">15 years of age\" it lists \"1,200 mg/day\". so the ceiling depends on the condition and on the formulation. in singapore the prescriber sets the dose and adjusts it on plasma levels.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["liver, kidney, heart or blood disorders (healthhub)","asian patients starting it — healthhub says hsa makes hla-b*1502 testing compulsory","pregnancy or planning one — nhs asks that a doctor be told immediately","atrioventricular block, past bone-marrow depression or porphyria (sg label)"],"clashes":[{"src":["ndf_tegretol_contra"],"note":"the sg label lists this combination as a contraindication","with":"monoamine-oxidase inhibitors (maois)"},{"src":["hh_carba_avoid","nhs_carba_mix"],"note":"healthhub and nhs: carbamazepine can make pills, patches, rings, implants and iuds less effective","with":"hormonal contraception and hrt"},{"src":["hh_carba_avoid"],"note":"healthhub: side effects rise and the antibiotics work less well","with":"erythromycin and clarithromycin"},{"src":["hh_carba_avoid","nhs_carba_mix"],"food":true,"note":"healthhub and nhs: raises the chance of carbamazepine side effects","with":"grapefruit and grapefruit juice"},{"src":["nhs_carba_mix"],"note":"nhs lists these among medicines that may not mix well","with":"warfarin and some other anticoagulants"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 6 carbamazepine rows, 27 Aug 2026","quote":"TEGRETOL 200 SIN00352P, TEGRETOL CR 200 SIN02387P, TEGRETOL CR 400 SIN02388P, Tegretol Oral Suspension 2% SIN00510P, APO-CARBAMAZEPINE SIN05735P and STORILAT 200 SIN05583P — all six rows read \"Prescription Only\", ATC N03AF01","accessed":"2026-08-27"},{"id":"ndf_tegretol_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 TABLET 200 MG [SIN00352P], Indications (SG package insert)","quote":"Epilepsy – Complex or simple partial seizures … Generalized tonic-clonic seizures … Tegretol is suitable for both monotherapy and combination therapy. Acute mania and maintenance treatment of bipolar affective disorders … Idiopathic trigeminal neuralgia","accessed":"2026-08-27"},{"id":"ndf_tegretol_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 [SIN00352P], Dosage regimen and administration (adults, epilepsy)","quote":"Initially, 100 to 200 mg once or twice daily; the dosage should be slowly raised until … an optimum response is obtained. In some patients 1,600 mg or even 2,000 mg daily may be appropriate.","accessed":"2026-08-27"},{"id":"ndf_tegretol_maxdose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 [SIN00352P], maximum recommended dose statements","quote":"However, the maximum daily dose of oral suspension is limited to 1,200 mg … Maximum recommended dose is 1,200 mg/day … >15 years of age: 1,200 mg/day.","accessed":"2026-08-27"},{"id":"ndf_tegretol_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 [SIN00352P], method of administration","quote":"The tablets and the oral suspension (to be shaken before use) may be taken during, after, or between meals. Tablets should be taken with a little liquid.","accessed":"2026-08-27"},{"id":"ndf_tegretol_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 [SIN00352P], Product information block","quote":"CARBAMAZEPINE - 200 MG · Forensic Classification: PRESCRIPTION ONLY MEDICINES · Anatomical Therapeutic Chemical (ATC) code N03AF01 · Licence Holder NOVARTIS (SINGAPORE) PTE LTD","accessed":"2026-08-27"},{"id":"ndf_tegretol_contra","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin00352p/","label":"MOH National Drug Formulary — TEGRETOL 200 [SIN00352P], Contraindications","quote":"Patients with atrioventricular block. Patients with a history of bone-marrow depression. Patients with a history of hepatic porphyrias … contraindicated in combination with monoamine-oxidase inhibitors (MAOIs) … Neonates below 4 weeks of age","accessed":"2026-08-27"},{"id":"hh_carba_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carbamazepine","label":"HealthHub (National Medication Information workgroup / Pharmaceutical Society of Singapore) — Carbamazepine: what is this medication for","quote":"Carbamazepine is used to control some types of seizures … also … as a mood stabilizer to help reduce mood swings in a condition known as bipolar disorder … trigeminal neuralgia … nerve pain at the face area.","accessed":"2026-08-27"},{"id":"hh_carba_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carbamazepine","label":"HealthHub — Carbamazepine: how should I take or use this medication","quote":"To reduce stomach upset, you can take this medication after food … These tablets are specially designed to release the medication slowly … it may take up to a few weeks before this medication can work fully.","accessed":"2026-08-27"},{"id":"hh_carba_prec","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carbamazepine","label":"HealthHub — Carbamazepine: what precautions should I take","quote":"According to the Health Science Authority (HSA) regulation, it is compulsory for all Asian patients who are first prescribed with carbamazepine to be tested for the specific gene (HLA-B*1502) … Liver problems; Kidney problems; Heart problems; Blood related diseases","accessed":"2026-08-27"},{"id":"hh_carba_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/carbamazepine","label":"HealthHub — Carbamazepine: what food or medication should I avoid","quote":"Carbamazepine may decrease the effectiveness of hormonal contraceptives … Antibiotics such as erythromycin and clarithromycin should not be taken with carbamazepine … Avoid eating grapefruit or drinking grapefruit juice","accessed":"2026-08-27"},{"id":"nhs_carba_about","url":"https://www.nhs.uk/medicines/carbamazepine/","label":"NHS medicines A–Z — Carbamazepine (Tegretol), reviewed 6 August 2026","quote":"Carbamazepine is an anti-seizure medicine used to treat epilepsy. It's also used to help nerve pain and bipolar disorder. It's only available with a prescription.","accessed":"2026-08-27"},{"id":"nhs_carba_side","url":"https://www.nhs.uk/medicines/carbamazepine/","label":"NHS medicines A–Z — Carbamazepine: side effects","quote":"Common side effects of carbamazepine include: dizziness; tiredness; dry mouth; changes to your coordination, balance and speech … an itchy or painful rash, mouth ulcers or blisters and trouble breathing – this could be a sign of Stevens-Johnson syndrome","accessed":"2026-08-27"},{"id":"nhs_carba_mix","url":"https://www.nhs.uk/medicines/carbamazepine/","label":"NHS medicines A–Z — Carbamazepine: taking carbamazepine with other medicines, food and drink","quote":"some types of hormonal contraception … HRT (hormone replacement therapy) medicines; aripiprazole … warfarin and some other medicines to help prevent blood clots … Do not drink grapefruit juice or eat grapefruit while taking carbamazepine","accessed":"2026-08-27"},{"id":"nhs_carba_preg","url":"https://www.nhs.uk/medicines/carbamazepine/","label":"NHS medicines A–Z — Carbamazepine: pregnancy","quote":"If you're taking carbamazepine and are planning a pregnancy or you get pregnant, tell your doctor immediately. If you need to take carbamazepine for epilepsy, you must use reliable contraception to avoid getting pregnant.","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}