{"ok":true,"entry":{"slug":"calcium-akg","kind":"supplement","name":"calcium alpha-ketoglutarate","aliases":["Ca-AKG","alpha-ketoglutarate"],"brands_sg":[],"class":"specialty compound","tags":["general","fitness"],"use_for":"limited human evidence — an SG trial is under way","use_after":null,"use_duration":null,"take_with":null,"pros":["an SG RCT is testing 1 g a day over 6 months","not named in HSA's prohibited or restricted annexes"],"cons":["no efficacy results published from that trial yet","optimal dose and long-term effects are unsettled","one pre-workout with AAKG underperformed plain caffeine"],"dose_note":"a Singapore trial uses 1 g a day of sustained-release calcium alpha-ketoglutarate for 6 months in adults aged 40–60; no efficacy results are published","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["calcium from Ca-AKG counts toward HSA's 1200 mg/day calcium cap","no upper limit set for AKG — absence of a cap is not safety"],"clashes":[],"sources":[{"id":"able","url":"https://europepmc.org/article/MED/40819772","label":"Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE) (Exp Gerontol 2025)","quote":"ABLE is a double-blind, placebo-controlled randomized trial assessing the effects of 1 g sustained-release calcium alpha-ketoglutarate versus placebo over 6 months … in 120 generally healthy adults … aged 40-60 years … living in Singapore","accessed":"2026-08-27"},{"id":"akg_review","url":"https://europepmc.org/article/PMC/PMC11597751","label":"Impact of Alpha-Ketoglutarate on Skeletal Muscle Health and Exercise Performance: A Narrative Review (Nutrients 2024)","quote":"research gaps remain in understanding AKG's long-term effects, optimal dosage, and specific pathways, particularly across diverse populations","accessed":"2026-08-27"},{"id":"mips2022","url":"https://europepmc.org/article/PMC/PMC9105861","label":"Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance (Nutrients 2022)","quote":"a multi-ingredient pre-workout supplement (MIPS) containing beta-alanine, L-citrulline malate, arginine alpha-ketoglutarate … Bench press repetition volume was greater after anhydrous caffeine than MIPS supplementation","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in health supplements and traditional medicines (Oct 2025), Annexes A and B","quote":"Annex A: List of substances which are prohibited or restricted for use with conditions … Annex B: List of substances with potential safety issues [alpha-ketoglutarate appears in neither annex]","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"Table 5: Minerals Limits … Calcium 1200 mg [maximum daily limit; no row for alpha-ketoglutarate in Table 4 or Table 5]","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}