{"ok":true,"entry":{"slug":"butchers-broom","kind":"supplement","name":"butcher's broom","aliases":["Ruscus aculeatus"],"brands_sg":["Swanson Vitamins","Nature's Way","Nature's Answer","Solaray","Nutricost"],"class":"botanical","tags":["heart"],"use_for":"leg symptoms and swelling in chronic venous disease","use_after":null,"use_duration":null,"take_with":null,"pros":["grade a evidence for leg pain and heaviness","reviewers rank it alongside mpff as best evidenced","rct data support relief of cvd symptoms and edema"],"cons":["evidence is for the combination, not ruscus alone","not among the phlebotonics in the 2020 cochrane review","acidity, epigastralgia and diarrhoea reported in 7.9%"],"dose_note":"the 2025 venoactive-compounds review tabulates ruscus extract at 300 mg a day; the trials behind its grade a ratings tested ruscus extract together with hesperidin methyl chalcone and ascorbic acid, not ruscus on its own","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["adverse events in the pooled combination trials ran at 7.89% — acidity, epigastralgia, diarrhoea","sg: a health supplement cannot be sold to treat circulatory disease (hsa table 6)","not listed in hsa annex a or annex b — that is absence of a restriction, not a safety verdict"],"clashes":[],"sources":[{"id":"gloviczki2025","url":"https://europepmc.org/article/PMC/PMC12219339","label":"The role of venoactive compounds in the treatment of chronic venous disease (Gloviczki, Kakkos, Urbanek, Chuback, Nicolaides; J Vasc Surg Venous Lymphat Disord 2025) — Table I dosages and Table IV evidence grades","quote":"Micronized purified flavonoid fraction (MPFF) and Ruscus extract combined with hesperidin methyl chalcone and ascorbic acid had the highest, mostly level A, quality of evidence.","accessed":"2026-08-27"},{"id":"bihari2022","url":"https://europepmc.org/article/PMC/PMC9331752","label":"Clinical Perspectives and Management of Edema in Chronic Venous Disease—What about Ruscus? (Bihari, Guex, Jawien, Szolnoky; Medicines 2022)","quote":"Data from randomized controlled trials support guideline recommendations for the use of Ruscus extract, hesperidin methyl chalcone and vitamin C to relieve major CVD-related symptoms and edema.","accessed":"2026-08-27"},{"id":"cochrane_phlebo2020","url":"https://europepmc.org/article/PMC/PMC8094625","label":"Phlebotonics for venous insufficiency (Martinez-Zapata et al., Cochrane Database of Systematic Reviews 2020, CD003229.pub4)","quote":"Moderate-certainty evidence suggests that phlebotonics probably reduce oedema slightly in the lower legs, compared with placebo … probably make little or no difference in QoL … probably increase adverse events slightly","accessed":"2026-08-27"},{"id":"hsa_annex","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A (105 rows) and Annex B (4 rows) — read from the cached PDF text on disk","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_tables","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), section 4.8 with Tables 4 and 5 (vitamins and minerals limits) — read from the cached PDF text on disk","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), section 6.6 and Table 6: diseases/conditions not allowed for health supplements — read from the cached PDF text on disk","quote":"HS must not be labelled, advertised or promoted for any specific medicinal purpose … Blood and circulatory system: Hypertension, stroke, cholesterol disorders, reduces cholesterol, regulates platelet aggregation, coagulation defects, arteriosclerosis","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/butcher-s-broom","label":"iHerb Singapore — Butcher's Broom category page, default order, '1 - 6 of 6 results', read 27 Aug 2026 via WebFetch","quote":"Butcher's Broom … Swanson Vitamins … Nature's Way … Nature's Answer … Solaray … Nutricost … Solaray","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}