{"ok":true,"entry":{"slug":"bromhexine","kind":"medication","name":"bromhexine","aliases":["Bisolvon","bromhexine HCl"],"brands_sg":["Duro-Tuss Chesty Cough","Mucolix","Vasican","Hosolvon","Axcel Bromhexine"],"class":"mucolytic","tags":["respiratory","cold-flu"],"use_for":"chesty cough — thins and loosens mucus in the airways","use_after":"three times a day per label · with or without food","use_duration":null,"take_with":"with or without food · syrups shaken first (healthhub)","pros":["healthhub: may be taken with or without food","one trial in the cochrane review favoured mucolytics","two sg products are general sale list — off the shelf"],"cons":["7 of 9 sg registrations are prescription only","cochrane: no good evidence for or against otc cough","nausea, vomiting and abdominal pain are common"],"dose_note":"no singapore product insert with a dose table could be found; the closest label is the bisolvon chesty forte data sheet (bromhexine hcl 8 mg), which reads 'Adults and children 12 years and over: One tablet (8 mg) three times a day when necessary. May be increased to two tablets (16 mg) three times a day for the first seven days' and 'Do not use in children under 6 years of age'; sg registrations are 8 mg tablets and 4 mg/5 ml elixirs/syrups, so strengths differ — healthhub adds that if symptoms persist or worsen after one week, speak to your healthcare professional; as directed on the label or by your doctor or pharmacist","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["gastric ulcer, liver or kidney problems — healthhub says say so first","copd or severe uncontrolled asthma — healthhub says say so first","pregnant or breastfeeding — the bisolvon data sheet says avoid","under 6 — bisolvon data sheet says do not use; 6–11 only on advice"],"clashes":[{"src":["medsafe_bisolvon_interact"],"note":"bisolvon data sheet: no clinically relevant unfavourable interactions reported with these medicines","with":"ampicillin, oxytetracycline, erythromycin"},{"src":["medsafe_bisolvon_interact"],"note":"bisolvon data sheet: interaction studies were not performed — untested, not shown safe","with":"oral anticoagulants, digoxin"},{"src":["healthhub_brom_precautions"],"note":"healthhub asks that you tell your healthcare professional what else you are taking","with":"other herbal products, supplements or medicines"}],"sources":[{"id":"healthhub_brom","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bromhexine","label":"HealthHub (MOH Singapore) — Bromhexine, uses / administration / side effects (article last reviewed 17 Mar 2026)","quote":"Bromhexine is a type of mucolytic that works by thinning and loosening mucus or phlegm in the airways … You may take Bromhexine with or without food … Common side effects may include nausea, vomiting and abdominal pain","accessed":"2026-08-27"},{"id":"healthhub_brom_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/bromhexine","label":"HealthHub (MOH Singapore) — Bromhexine, precautions and interactions sections (article last reviewed 17 Mar 2026)","quote":"gastric ulcers, liver or kidney problems and lung conditions e.g. Chronic Obstructive Lung Disease (COPD) or severe uncontrolled asthma … Let your healthcare professional know if you are taking … any other herbal products, supplements, or medications","accessed":"2026-08-27"},{"id":"medsafe_bisolvon","url":"https://www.medsafe.govt.nz/profs/datasheet/b/bisolvontabsol.pdf","label":"Medsafe (New Zealand) Data Sheet — BISOLVON CHESTY FORTE bromhexine hydrochloride tablets and oral solution, section 4.2 dose (ds4, 20 Dec 2021)","quote":"Adults and children 12 years and over: One tablet (8 mg) three times a day when necessary. May be increased to two tablets (16 mg) three times a day for the first seven days.","accessed":"2026-08-27"},{"id":"medsafe_bisolvon_warn","url":"https://www.medsafe.govt.nz/profs/datasheet/b/bisolvontabsol.pdf","label":"Medsafe (New Zealand) Data Sheet — BISOLVON CHESTY FORTE, sections 4.2/4.3/4.4 age limits and precautions","quote":"Do not use in children under 6 years of age. Use in children aged 6 to 11 years only on the advice of a doctor, pharmacist or nurse practitioner … caution in patients with severe liver disease and severe renal failure","accessed":"2026-08-27"},{"id":"medsafe_bisolvon_interact","url":"https://www.medsafe.govt.nz/profs/datasheet/b/bisolvontabsol.pdf","label":"Medsafe (New Zealand) Data Sheet — BISOLVON CHESTY FORTE, sections 4.5/4.6 interactions, pregnancy and lactation","quote":"No clinically relevant unfavourable interactions … such as ampicillin, oxytetracycline or erythromycin, have been reported. Interaction studies with oral anticoagulants or digoxin were not performed … preferable to avoid the use … during pregnancy … should not be used during breast-feeding","accessed":"2026-08-27"},{"id":"ndf_durotuss_chesty","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin10014p/","label":"MOH National Drug Formulary — DURO-TUSS CHESTY COUGH LIQUID [SIN10014P] (HSA-registered product record)","quote":"DURO-TUSS CHESTY COUGH LIQUID [SIN10014P] … BROMHEXINE HCL - 12 MG/15 ML … Forensic Classification: GENERAL SALE LIST … Licence Holder: INOVA PHARMACEUTICALS (SINGAPORE) PTE. LIMITED","accessed":"2026-08-27"},{"id":"hsa_register_brom","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA register of therapeutic products (data.gov.sg open data d_767279312753558cbf19d48344577084, datastore_search API) — bromhexine rows","quote":"Productname: HOSOLVON TABLET 8 mg … Strength: 8.00mg … Forensicclassification: Prescription Only … Productname: DURO-TUSS CHESTY COUGH LIQUID … General Sale List … Productname: MUCOLIX ELIXIR 4 mg/5 ml … General Sale List","accessed":"2026-08-27"},{"id":"cochrane2014","url":"https://europepmc.org/article/PMC/PMC7061814","label":"Cochrane Database of Systematic Reviews — Over-the-counter (OTC) medications for acute cough in children and adults in community settings (Smith, Schroeder, Fahey 2014; PMC7061814)","quote":"One trial found that a mucolytic reduced cough frequency and symptom scores … The results of one trial favoured active treatment with mucolytics over placebo … There is no good evidence for or against the effectiveness of OTC medicines in acute cough","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:14.713299+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}