{"ok":true,"entry":{"slug":"blueberry-extract","kind":"supplement","name":"blueberry extract","aliases":["Vaccinium corymbosum","blueberry concentrate"],"brands_sg":["California Gold Nutrition","Natural Factors","Nutricost","Life Extension","Micro Ingredients"],"class":"botanical","tags":["general","heart"],"use_for":"vascular measures moved in 14 rcts; cognition did not","use_after":null,"use_duration":null,"take_with":null,"pros":["14 rcts, 632 healthy adults were pooled in 2026","flow-mediated dilation rose 1.11% (ci 0.50 to 1.72)","pooled from randomised controlled trials only"],"cons":["no significant effect on executive function or mood","blood pressure did not move: sbp -0.11 mmhg, ns","dose, berry type and duration varied across the trials"],"dose_note":"the 2026 systematic review and meta-analysis pooled 14 randomised controlled trials in 632 healthy adults and names heterogeneity in blueberry dosage, type, intervention duration and participant age as a limitation, so no single dose can be quoted; singapore listings run 160 mg to 500 mg per capsule alongside whole-berry powders","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["the cognitive claim is the selling point; the pooled trials did not show it","the pooled trials were in healthy adults, not people with memory complaints","singapore does not allow dementia, alzheimer's or hypertension claims on supplements","not listed in hsa annex a or b — absence of a listing is not a safety finding"],"clashes":[],"sources":[{"id":"he2026","url":"https://europepmc.org/article/MED/41974068","label":"Blueberry consumption enhances vascular function but not cognitive abilities in healthy individuals: a systematic review and meta-analysis (He et al., Nutrition Research 2026)","quote":"we analyzed 14 randomized controlled trials (RCTs) involving 632 participants … blueberry intervention significantly improved flow-mediated dilation (FMD) by 1.11% … Cognitive outcomes showed no significant effect executive function (SMD: 0.21; 95% CI: -0.05, 0.46)","accessed":"2026-08-27"},{"id":"hsa_annex","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A and Annex B — read from the cached PDF text on disk","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_tables","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines, GL-CHPB-3-001 Rev. No. 020 (January 2026), Tables 4 and 5 (vitamins and minerals limits) — read from the cached PDF text on disk","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_table6","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), Table 6: examples of diseases/conditions/disorders not allowed for health supplements","quote":"Brain and nervous system: Epilepsy, fits, paralysis, Alzheimer's disease, Parkinsonism, dementia, neuropathies, drug addictions, depression, eating disorders","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/blueberry-extract","label":"iHerb Singapore — Blueberry Supplement category (default order, 1 - 12 of 12 results)","quote":"California Gold Nutrition, MEM Food, Memory & Cognitive Support … Natural Factors, BlueRich, Super Strength Blueberry Concentrate, 500 mg … Nutricost, Blueberry Extract, 160 mg … Life Extension, Blueberry Extract Capsules … Micro Ingredients, Organic Blueberry Extract Powder","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:12.75901+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}