{"ok":true,"entry":{"slug":"bifidobacterium-longum","kind":"supplement","name":"bifidobacterium longum","aliases":["B. longum","BB536"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"probiotic","tags":["gut","cognitive"],"use_for":"constipation in older adults · ibs pain, strain-specific","use_after":"daily","use_duration":"the bb536 constipation trial ran 4 weeks","take_with":"water · cfu at end of shelf life is the number that counts","pros":["bb536 5x10^10 cfu/day raised stool frequency","b. longum 35624 met the bar in a 2026 ibs review","unlikely to harm healthy people; gas is the usual"],"cons":["bb536 missed its primary endpoint (p=0.074)","cognitive data: one 22-person single-blind trial","a perinatal mood rct found no difference vs placebo"],"dose_note":"trials use 5 x 10^10 cfu/day of bb536 for 4 weeks in older adults with chronic constipation, and 2 x 10^10 cfu/day of olp-01 for 12 weeks in post-stroke patients; no rda, ul or fda dv exists for live microorganisms; hsa sets no daily limit and no probiotic appears on its prohibited/restricted annexes","dosage":{"ul":null,"unit":"CFU/day","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severely ill or immunocompromised — bacteremia and fungemia reported; ask your doctor first","preterm infants — fda warns of severe, potentially fatal infection; a hospital decision only","in intensive care or with a central line — the reported cases cluster there; ask your doctor"],"clashes":[],"sources":[{"id":"nccih_prob_constip","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — Constipation (2017 evaluation of 9 studies)","quote":"A 2017 evaluation of 9 studies (778 participants) of probiotics for constipation in elderly people indicated that probiotics produced a small but meaningful benefit. The type of bacteria most often tested was Bifidobacterium longum","accessed":"2026-08-27"},{"id":"nih_ods_prob_ibs","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Irritable bowel syndrome (meta-analysis of 10 RCTs, 877 adults)","quote":"a meta-analysis of 10 RCTs … 877 adults … probiotics that contained Bifidobacterium breve, Bifidobacterium longum, or Lactobacillus acidophilus species had lower pain scores than those who received placebo","accessed":"2026-08-27"},{"id":"nih_ods_prob_strain","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Identification / Mechanisms of action (read via archive.org; ods.od.nih.gov is Cloudflare-blocked)","quote":"Because the effects of probiotics can be specific to certain probiotic strains, recommendations for their use in the clinic need to be strain-specific … Probiotics may transiently colonize the human gut mucosa in highly individualized patterns","accessed":"2026-08-27"},{"id":"nih_ods_prob_cfu","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (CFU labelling, shelf life)","quote":"Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain 50 billion CFU or more. However, products with higher CFU counts are not necessarily more effective","accessed":"2026-08-27"},{"id":"nih_ods_prob_shelf","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (viability at end of shelf life)","quote":"probiotics must be consumed alive … users should look for products labeled with the number of CFU at the end of the product's shelf life, not at the time of manufacture","accessed":"2026-08-27"},{"id":"nih_ods_prob_safety","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Safety Considerations","quote":"Probiotics are unlikely to cause harm in healthy people, and side effects are usually minor … linked to a few cases of bacteremia, fungemia, and infections … most of these cases involved individuals who were severely ill or immunocompromised","accessed":"2026-08-27"},{"id":"nccih_prob_harm","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — Can probiotics be harmful? / FDA 2023 preterm warning","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … the FDA warned health care providers that premature infants who are given probiotics are at risk of severe, potentially fatal infections","accessed":"2026-08-27"},{"id":"ibs_sr2026","url":"https://europepmc.org/article/PMC/PMC12898053","label":"Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome (Maslennikov et al., J Clin Med 2026; 32 RCTs, 10 strains)","quote":"Meta-analyses demonstrated the efficacy of Bifidobacterium longum (formerly Bifidobacterium infantis) 35624 … and Bacillus coagulans Unique IS2 (MTCC 5260) … did not demonstrate the efficacy of Escherichia coli Nissle 1917, Lactobacillus gasseri BNR17, or Lactobacillus casei Shirota","accessed":"2026-08-27"},{"id":"bb536_constip2023","url":"https://europepmc.org/article/PMC/PMC9973440","label":"Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial (Am J Gastroenterol 2023; n=79)","quote":"B. longum BB536, 5 x 10^10 colony-forming unit … once daily for up to 4 weeks … The primary end point was not significant (P = 0.074) … significant difference … on the stool frequency (P = 0.008)","accessed":"2026-08-27"},{"id":"blongum_cog2026","url":"https://europepmc.org/article/PMC/PMC12965072","label":"Effect of Bifidobacterium longum on cognition and microbiota in post-stroke patients: a single-blinded, controlled trial (Int J Med Sci 2026; n=22)","quote":"Supplementation of Bifidobacterium longum OLP-01 at a dose of 2 x 10^10 CFU daily for 12 weeks improved cognitive function and changes gut microbiota, but did not alter physical performance in post-stroke patients","accessed":"2026-08-27"},{"id":"blongum_mood2025","url":"https://europepmc.org/article/PMC/PMC11965328","label":"The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial (Sci Rep 2025; N=184)","quote":"Contrary to our hypothesis, we did not observe any differences between groups in mood outcomes … BL NCC3001 was not detected after the intervention in all of the intervention group participants","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), s3.1 working definition; Table 2 microbial limits; Tables 4–5 cover vitamins and minerals only","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … The above limits for total aerobic microbial count, and yeast and mould may not be applicable to certain products such as probiotics","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B","quote":"to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no probiotic, Lactobacillus, Bifidobacterium, Bacillus or Akkermansia row appears in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — 'Probiotic Supplements for Gut Health' category page, default order (page now Cloudflare-blocked; row carried over from the KB's probiotics entry, same access date)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics … 21st Century, Cranberry Plus Probiotic … Garden of Life, Dr. Formulated Probiotics, Once Daily Women's, 50 Billion … NOW Foods, Probiotic-10™ … Lemme, Purr, Vaginal Probiotic Gummies","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}