{"ok":true,"entry":{"slug":"bifidobacterium-lactis","kind":"supplement","name":"bifidobacterium lactis","aliases":["B. lactis","BB-12","HN019","Bifidobacterium animalis"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"probiotic","tags":["gut","immune"],"use_for":"constipation and ibs symptoms — strain-specific data","use_after":null,"use_duration":"the hn019 trials ran 28 days, the ibs trial six weeks","take_with":null,"pros":["constipation review favoured b. lactis specifically","hn019 raised bowel movements in low-frequency adults","bb-12 cut infant crying time vs placebo (n=80)"],"cons":["hn019 missed its primary endpoint, colonic transit","that benefit came from a post-hoc subgroup of 65","immune data mixes lab work with human studies"],"dose_note":"the hn019 constipation trial used 1×10^9 or 1×10^10 cfu a day for 28 days; the bb-12 colic trial used 1×10^9 cfu a day","dosage":{"ul":null,"unit":"CFU","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severe illness or weakened immunity — higher risk of harm","premature infants — fda warned of severe or fatal infections"],"clashes":[],"sources":[{"id":"nccih_probiotics","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety","quote":"A 2014 review of 14 studies (1,182 participants) of probiotics for constipation in adults showed some evidence of benefit, especially for Bifidobacterium lactis.","accessed":"2026-08-27"},{"id":"nccih_safety","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety, \"Can probiotics be harmful?\"","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … Cases of severe or fatal infections have been reported in premature infants who were given probiotics","accessed":"2026-08-27"},{"id":"ibarra2018","url":"https://europepmc.org/article/MED/29227175","label":"Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and GI symptoms in functional constipation (Ibarra et al., Gut Microbes 2018)","quote":"no statistically significant differences in the primary or secondary outcomes … A post hoc analysis of 65 participants … showed a physiologically relevant increase in weekly BMF … 1 × 10^9 or 1 × 10^10 CFU of HN019/day","accessed":"2026-08-27"},{"id":"nocerino2020","url":"https://europepmc.org/article/MED/31797399","label":"The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12 in infant colic (Nocerino et al., Aliment Pharmacol Ther 2020)","quote":"The rate of infants with reduction of ≥50% of mean daily crying duration was higher in infants treated with BB-12 … Eighty infants were randomised … BB-12 (1 × 10^9 CFU/day) or placebo for 28 days","accessed":"2026-08-27"},{"id":"cheng2021","url":"https://europepmc.org/article/MED/34970580","label":"Bifidobacterium animalis subsp. lactis HN019 effects on gut health: a review (Cheng et al., Front Nutr 2021)","quote":"B. lactis HN019™ has a beneficial role in maintaining intestinal barrier function … regulating host immune defense toward pathogens in both in vitro and human studies … reduced intestinal transit time and increased bowel movement frequency in functional constipation","accessed":"2026-08-27"},{"id":"martoni2020","url":"https://europepmc.org/article/MED/32019158","label":"Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 improve abdominal pain severity and symptomology in IBS (Martoni et al., Nutrients 2020)","quote":"Three hundred and thirty adults … with IBS … Bifidobacterium animalis subsp. lactis UABla-12 (1 × 10^10 CFU/day) over six weeks … APS-NRS was significantly improved in both probiotic groups vs. placebo","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — Probiotics category page (default best-selling order)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics, 60 Veggie Capsules","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on prohibited and restricted ingredients in HS and TM (Oct 2025), Annex A/B","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), working definition and Tables 4–5","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … Table 4: Vitamins Limits … Table 5: Minerals Limits","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:38.376296+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}