{"ok":true,"entry":{"slug":"betaine-hcl","kind":"supplement","name":"betaine HCl","aliases":["betaine hydrochloride"],"brands_sg":["NOW Foods","Doctor's Best","Nutricost","Enzymedica","Thorne"],"class":"digestive acid","tags":["gut"],"use_for":"brief stomach re-acidification when acid is low","use_after":"trials dosed 1500 mg with water, not with a meal","use_duration":null,"take_with":"90 ml of water in the trial that measured gastric ph","pros":["lowered gastric ph by 4.5 units in a 6-person trial","onset was fast — mean 6.3 min to ph under 3","restored dasatinib uptake under low-acid conditions"],"cons":["effect is brief — ph under 3 for about 73 minutes","trials were small and used drug-induced low acid","hsa does not approve supplements before sale in sg"],"dose_note":"the gastric-ph trials used a single 1500 mg oral dose of anhydrous betaine HCl with 90 mL water","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["studied in healthy volunteers with drug-induced low acid — not in reflux, gastritis or ulcer","it acidifies the stomach, so absorption of ph-dependent medicines can change","not named in hsa's prohibited/restricted annex — that list is not exhaustive","hsa does not approve health supplements before sale in singapore"],"clashes":[{"src":["yago2013","yago2014"],"note":"betaine hcl transiently reverses the raised gastric ph these drugs produce","with":"acid-reducing drugs (e.g. rabeprazole, a ppi)"},{"src":["yago2014"],"note":"raised dasatinib cmax 15-fold and auc 6.7-fold under drug-induced low acid","with":"ph-dependent oral drugs (e.g. dasatinib)"}],"sources":[{"id":"yago2013","url":"https://europepmc.org/article/PMC/PMC3946491","label":"Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria (Yago et al., Mol Pharm 2013)","quote":"Six healthy volunteers … 1500 mg of betaine HCl was given orally with 90 mL of water … Betaine HCl significantly lowered gastric pH by 4.5 (± 0.5) units from 5.2 (± 0.5) to 0.6 (± 0.2)","accessed":"2026-08-27"},{"id":"yago2013_dur","url":"https://europepmc.org/article/PMC/PMC3946491","label":"Yago 2013 — onset and duration of gastric reacidification","quote":"The onset of effect of betaine HCl was rapid, with a mean time to pH < 3 of 6.3 (± 4.3) min. The reacidification period was temporary with a gastric pH < 3 … lasting 73 (± 33) … min","accessed":"2026-08-27"},{"id":"yago2014","url":"https://europepmc.org/article/PMC/PMC4389759","label":"The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria (Yago et al., AAPS J 2014)","quote":"coadministration of BHCl significantly increased dasatinib Cmax and AUC0-∞ by 15- and 6.7-fold, restoring them to 105 and 121%, respectively, of the control (dasatinib alone)","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA Guidelines on prohibited and restricted ingredients in HS and TM (GL-CHPB-1-012, Oct 2025), s1.3 / Annex A","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Health Supplements Guidelines (GL-CHPB-3-001 Rev. 020, Jan 2026), s8.1","quote":"Currently, HS are not subject to premarket approval and licensing by HSA for their importation, manufacture and sales in Singapore.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/betaine-hcl","label":"iHerb Singapore — Betaine HCl category (default best-selling order)","quote":"NOW Foods … Doctor's Best … Nutricost … Enzymedica … Thorne","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Thorne","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":66}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}