{"ok":true,"entry":{"slug":"bacillus-coagulans","kind":"supplement","name":"bacillus coagulans","aliases":["B. coagulans","GBI-30","LactoSpore","Weizmannia coagulans"],"brands_sg":["California Gold Nutrition","21st Century","Garden of Life","NOW Foods","Lemme"],"class":"spore probiotic","tags":["gut"],"use_for":"ibs symptoms and quality of life — by strain, not species","use_after":"daily","use_duration":"the constipation trial ran 21 days","take_with":"water · a spore former, resilient to processing","pros":["unique is2 improved key ibs symptoms in a 2026 review","mtcc 5856 improved quality of life in ibs","bc01 5x10^9 cfu/day eased functional constipation"],"cons":["results are strain-level; the species is not the claim","the constipation trial was unbalanced, 79 vs 34","renamed twice — weizmannia, heyndrickxia on labels"],"dose_note":"the functional-constipation trial used 5 x 10^9 cfu/day of weizmannia coagulans bc01 for 21 days; the ibs meta-analyses that came out positive were for unique is2 (mtcc 5260) and mtcc 5856, not for the species as a whole; no rda, ul or fda dv exists for live microorganisms; hsa sets no daily limit and no bacillus appears on its prohibited/restricted annexes","dosage":{"ul":null,"unit":"CFU/day","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["severely ill or immunocompromised — bacteremia and fungemia reported; ask your doctor first","preterm infants — fda warns of severe, potentially fatal infection; a hospital decision only","in intensive care or with a central line — the reported cases cluster there; ask your doctor"],"clashes":[],"sources":[{"id":"ibs_sr2026","url":"https://europepmc.org/article/PMC/PMC12898053","label":"Strain-Specific Systematic Review with Meta-Analysis of Probiotics Efficacy in the Treatment of Irritable Bowel Syndrome (Maslennikov et al., J Clin Med 2026; 32 RCTs, 10 strains)","quote":"Meta-analyses demonstrated the efficacy of Bifidobacterium longum (formerly Bifidobacterium infantis) 35624 … and Bacillus coagulans Unique IS2 (MTCC 5260) … did not demonstrate the efficacy of Escherichia coli Nissle 1917, Lactobacillus gasseri BNR17, or Lactobacillus casei Shirota","accessed":"2026-08-27"},{"id":"bc01_constip2025","url":"https://europepmc.org/article/PMC/PMC12747034","label":"Weizmannia coagulans BC01 supplementation improved functional constipation: a randomized, placebo-controlled clinical study (Medicine 2025; n=113)","quote":"113 patients diagnosed with functional constipation … randomly divided into BC01 (n = 79; received BC01 powder; 5 x 10^9 CFU/d) and placebo (n = 34) … No adverse events were observed throughout the trial period","accessed":"2026-08-27"},{"id":"hcoag_oral2025","url":"https://europepmc.org/article/PMC/PMC12864477","label":"Oral health benefits of Heyndrickxia coagulans: a systematic review and meta-analysis (Front Oral Health 2025; 8 studies)","quote":"Heyndrickxia coagulans (formerly Bacillus coagulans) is a spore-forming, lactic acid-producing bacterium … Its resilience to environmental stressors and industrial processing makes it a promising probiotic candidate","accessed":"2026-08-27"},{"id":"nih_ods_prob_strain","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Identification / Mechanisms of action (read via archive.org; ods.od.nih.gov is Cloudflare-blocked)","quote":"Because the effects of probiotics can be specific to certain probiotic strains, recommendations for their use in the clinic need to be strain-specific … Probiotics may transiently colonize the human gut mucosa in highly individualized patterns","accessed":"2026-08-27"},{"id":"nih_ods_prob_cfu","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (CFU labelling, shelf life)","quote":"Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain 50 billion CFU or more. However, products with higher CFU counts are not necessarily more effective","accessed":"2026-08-27"},{"id":"nih_ods_prob_shelf","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Dietary Supplements (viability at end of shelf life)","quote":"probiotics must be consumed alive … users should look for products labeled with the number of CFU at the end of the product's shelf life, not at the time of manufacture","accessed":"2026-08-27"},{"id":"nih_ods_prob_safety","url":"https://web.archive.org/web/2026/https://ods.od.nih.gov/factsheets/Probiotics-HealthProfessional/","label":"NIH ODS — Probiotics Fact Sheet for Health Professionals — Safety Considerations","quote":"Probiotics are unlikely to cause harm in healthy people, and side effects are usually minor … linked to a few cases of bacteremia, fungemia, and infections … most of these cases involved individuals who were severely ill or immunocompromised","accessed":"2026-08-27"},{"id":"nccih_prob_types","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — What types of bacteria are in probiotics?","quote":"Different types of probiotics may have different effects. For example, if a specific kind of Lactobacillus helps prevent an illness, that doesn't necessarily mean that another kind of Lactobacillus … would do the same thing","accessed":"2026-08-27"},{"id":"nccih_prob_harm","url":"https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know","label":"NIH NCCIH — Probiotics: Usefulness and Safety — Can probiotics be harmful? / FDA 2023 preterm warning","quote":"The risk of harmful effects from probiotics is greater in people with severe illnesses or compromised immune systems … the FDA warned health care providers that premature infants who are given probiotics are at risk of severe, potentially fatal infections","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (January 2026), s3.1 working definition; Table 2 microbial limits; Tables 4–5 cover vitamins and minerals only","quote":"Vitamins, minerals, amino acids, fatty acids, enzymes, probiotics and other bioactive substances … The above limits for total aerobic microbial count, and yeast and mould may not be applicable to certain products such as probiotics","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in HS and TM, GL-CHPB-1-012 Rev. 001 (October 2025), clause 1.3 + Annex A/B","quote":"to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list [no probiotic, Lactobacillus, Bifidobacterium, Bacillus or Akkermansia row appears in Annex A or B]","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/probiotics","label":"iHerb Singapore — 'Probiotic Supplements for Gut Health' category page, default order (page now Cloudflare-blocked; row carried over from the KB's probiotics entry, same access date)","quote":"California Gold Nutrition, LactoBif® 30 Probiotics … 21st Century, Cranberry Plus Probiotic … Garden of Life, Dr. Formulated Probiotics, Once Daily Women's, 50 Billion … NOW Foods, Probiotic-10™ … Lemme, Purr, Vaginal Probiotic Gummies","accessed":"2026-08-27"}],"brand_certs":[{"brand":"Garden of Life","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":23},{"brand":"Lemme","example":null,"programme":"NSF Certified for Sport","matching_products":0,"brand_total_certified":1}],"updated_at":"2026-08-30T17:59:36.026222+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}