{"ok":true,"entry":{"slug":"azelastine","kind":"medication","name":"azelastine","aliases":["Dymista (with fluticasone)"],"brands_sg":["Dymista","Synaze"],"class":"nasal antihistamine","tags":["allergy"],"use_for":"sg label: moderate to severe allergic rhinitis","use_after":"sg label: one spray in each nostril twice daily","use_duration":null,"take_with":"nasal route only · sg label: shake and prime the bottle","pros":["sg label: suitable for long-term use, no duration limit","sg label: no dose change in renal impairment","sg label: for adults and children 6 years and older"],"cons":["hsa: no azelastine-only product is registered in sg","us otc label: drowsiness and a bitter taste can occur","the two sg products add a steroid and need a script"],"dose_note":"in singapore azelastine exists only inside a fixed combination with fluticasone propionate. the sg label maximum, from the moh national drug formulary page for DYMISTA NASAL SPRAY [SIN15255P], is \"One spray in each nostril twice daily (morning and evening)\" for adults, adolescents and children 6 years and older, with \"DYMISTA nasal spray is not recommended for use in children below 6 years of age\" and \"DYMISTA nasal spray is suitable for long-term use. There is no restriction regarding duration of use.\" for azelastine on its own, the us otc drug facts label for Astepro Allergy (azelastine HCl 205.5 mcg per spray) caps adults and children 12 and over at \"do not use more than 4 sprays in each nostril in a 24 hour period\" and children 6 to 11 at \"do not use more than 2 sprays in each nostril in a 24 hour period\" — that product is not registered in singapore. the prescriber or pharmacist sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["under 6 years — the sg label does not recommend it","severe liver impairment — the sg label says caution is required","recent nose surgery, nose ulcers or an unhealed nose injury (us otc label)","pregnancy or breastfeeding — us otc label: ask a health professional first"],"clashes":[{"src":["fda_astepro_warn"],"food":true,"note":"us otc label: may increase the drowsiness that can occur with nasal azelastine","with":"alcohol, sedatives and tranquillisers"},{"src":["nhs_anti_mix"],"note":"nhs flags doubling up on antihistamine through an all-in-one remedy","with":"cough and cold remedies containing an antihistamine"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg dataset d_767279312753558cbf19d48344577084), Forensicclassification column; all 5,511 rows cached at /tmp/hsa_all.json and filtered locally (never re-fetched), 2 azelastine rows, 27 Aug 2026","quote":"DYMISTA NASAL SPRAY (SIN15255P) and SYNAZE NASAL SPRAY (SIN15256P) both read \"Prescription Only\", ATC R01AD58, active ingredients \"Azelastine hydrochloride&&Fluticasone propionate\" 0.1 %w/w&&0.0365 %w/w; no azelastine-only product is listed","accessed":"2026-08-27"},{"id":"ndf_dymista_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15255p/","label":"MOH National Drug Formulary — DYMISTA NASAL SPRAY [SIN15255P], Product information block","quote":"AZELASTINE HYDROCHLORIDE - 0.1% W/W; FLUTICASONE PROPIONATE - 0.0365% W/W … Forensic Classification: PRESCRIPTION ONLY MEDICINES · ATC code R01AD58 · Prescription-only Medicines with Exemptions for Supply without Prescription: NA","accessed":"2026-08-27"},{"id":"ndf_dymista_ind","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15255p/","label":"MOH National Drug Formulary — DYMISTA NASAL SPRAY [SIN15255P], Indications","quote":"Symptomatic treatment of moderate to severe allergic rhinitis and rhino-conjunctivitis in adults and children 6 years and older where use of a combination (intranasal antihistamine and glucocorticoid) is appropriate.","accessed":"2026-08-27"},{"id":"ndf_dymista_dose","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15255p/","label":"MOH National Drug Formulary — DYMISTA NASAL SPRAY [SIN15255P], Dosage and administration","quote":"One spray in each nostril twice daily (morning and evening) … not recommended for use in children below 6 years of age … suitable for long-term use. There is no restriction regarding duration of use.","accessed":"2026-08-27"},{"id":"fda_astepro_purpose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0640846-19a6-7f79-e053-2995a90a8176","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Astepro Allergy azelastine HCl 205.5 mcg per spray, Purpose and Uses","quote":"Purpose: Antihistamine. Uses: temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: nasal congestion; runny nose; sneezing; itchy nose","accessed":"2026-08-27"},{"id":"fda_astepro_dose","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0640846-19a6-7f79-e053-2995a90a8176","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Astepro Allergy azelastine HCl 205.5 mcg per spray, Directions","quote":"adults and children 12 years and older: … do not use more than 4 sprays in each nostril in a 24 hour period; children under 6 years: do not use","accessed":"2026-08-27"},{"id":"fda_astepro_warn","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e0640846-19a6-7f79-e053-2995a90a8176","label":"US FDA OTC Drug Facts (DailyMed/openFDA) — Astepro Allergy azelastine HCl 205.5 mcg per spray, Warnings","quote":"Ask a doctor before use if you have had recent nose ulcers or nose surgery … drowsiness may occur; avoid alcoholic drinks; alcohol, sedatives, and tranquilizers may increase drowsiness … you may get a bitter taste","accessed":"2026-08-27"},{"id":"nhs_anti_types","url":"https://www.nhs.uk/conditions/antihistamines/","label":"NHS — Antihistamines (conditions A–Z), types and forms","quote":"Antihistamines block the effects of a substance called histamine in your body … They also come in several different forms – including tablets, capsules, liquids, syrups, creams, lotions, gels, eyedrops and nasal sprays.","accessed":"2026-08-27"},{"id":"nhs_anti_mix","url":"https://www.nhs.uk/conditions/antihistamines/","label":"NHS — Antihistamines: taking antihistamines with other medicines, food or alcohol","quote":"Examples of medicines that could cause problems if taken with antihistamines include some types of: antidepressants; stomach ulcer or indigestion medicines; cough and cold remedies that also contain an antihistamine","accessed":"2026-08-27"},{"id":"ndf_dymista_admin","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15255p/","label":"MOH National Drug Formulary — DYMISTA NASAL SPRAY [SIN15255P], Method of administration","quote":"DYMISTA Nasal Spray is for administration by the nasal route only. Shake the bottle gently before each use for about 5 seconds … must be primed by pressing down and releasing the pump 6 times","accessed":"2026-08-27"},{"id":"ndf_dymista_special","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin15255p/","label":"MOH National Drug Formulary — DYMISTA NASAL SPRAY [SIN15255P], Dosing in special populations","quote":"No dose adjustment is required in patients with renal impairment or mild to moderate hepatic impairment … Caution is required when treating patients with severe hepatic impairment","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:12.75901+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}