{"ok":true,"entry":{"slug":"aripiprazole","kind":"medication","name":"aripiprazole","aliases":["Abilify"],"brands_sg":["Abilify","Abilify Maintena","Ariprip","Aripdon","Aripiprazole Mevon"],"class":"atypical antipsychotic","tags":["mental-health"],"use_for":"healthhub: schizophrenia, bipolar or depression symptoms","use_after":"healthhub: with or without food; depot given as injection","use_duration":null,"take_with":"water · healthhub: alcohol can cause excessive sleepiness","pros":["healthhub: for schizophrenia and bipolar symptoms","healthhub: may be taken with or without food","hh: tablet, oral solution or depot injection in sg"],"cons":["hh: restlessness, tremor, poor sleep, weight gain","healthhub: can worsen blood sugar control in diabetes","hh: rare urges to gamble, eat, shop or have sex"],"dose_note":"the us abilify label's dosage table gives a maximum of '30 mg/day' for schizophrenia (adults and adolescents) and for bipolar mania, '15 mg/day' as an add-on in adult major depressive disorder and for irritability in autistic disorder, and for tourette's disorder '10 mg/day' under 50 kg and '20 mg/day' at 50 kg or more. the same label halves the usual dose in known cyp2d6 poor metabolisers. sg-registered strengths are 2–15 mg tablets, 1 mg/ml oral solution and 400 mg depot. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["diabetes — healthhub: it may worsen blood sugar control","liver disease, heart-rhythm problems, stroke or blood clots (healthhub)","dementia, seizures, blood pressure or swallowing problems (healthhub)","under 25 — healthhub warns of new self-harm thoughts early on"],"clashes":[{"src":["hh_ari_avoid"],"food":true,"note":"healthhub: it can cause excessive sleepiness","with":"alcohol"},{"src":["fda_abilify_cyp"],"note":"us label: dose adjustment is specified for these combinations","with":"strong cyp2d6 inhibitors (quinidine, fluoxetine, paroxetine)"},{"src":["fda_abilify_cyp"],"note":"us label: a quarter of the usual dose in cyp2d6 poor metabolisers","with":"strong cyp3a4 inhibitors (itraconazole, clarithromycin)"},{"src":["hh_ari_precautions"],"note":"healthhub: some may affect how it works or cause serious drug interactions","with":"other medicines, supplements and traditional remedies"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, cached in full and filtered locally)","quote":"All 18 registered aripiprazole products carry 'Prescription Only' — ABILIFY TABLET 2/5/10/15 mg and ORAL SOLUTION 1MG/ML · ABILIFY MAINTENA 400 mg · ABILIFY ASIMTUFII 960MG · ARIPRIP · ARIPDON · ARIPIPRAZOLE MEVON","accessed":"2026-08-27"},{"id":"hh_ari_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub (National Medication Information workgroup, SG) — Aripiprazole: what is this medication for","quote":"Aripiprazole belongs to a class of medications known as atypical (second-generation) antipsychotics. It is used to treat and prevent the return of symptoms in Schizophrenia and other mental health related conditions … bipolar disorder … symptoms of depression","accessed":"2026-08-27"},{"id":"hh_ari_howto","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: how should I take this medication","quote":"Aripiprazole may be taken with or without food. Do not stop taking or adjust the dose of this medication without checking with your doctor … For Aripiprazole depot injection: Aripiprazole is injected into your upper arm or buttocks.","accessed":"2026-08-27"},{"id":"hh_ari_side","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: common side effects","quote":"Nausea, vomiting … Constipation … Difficulty sleeping … Drowsiness or feeling tired … Dizziness … Uncontrollable shaking of limbs (tremors) and/or restlessness … Increase in appetite, weight gain","accessed":"2026-08-27"},{"id":"hh_ari_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: what precautions should I take","quote":"You have diabetes. Aripiprazole may sometimes worsen blood sugar control in diabetes … Liver disease, irregular heartbeat or other heart problems, stroke, history of blood clots; Dementia, seizure (fits), high or low blood pressure … swallowing difficulties","accessed":"2026-08-27"},{"id":"hh_ari_rare","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: rare but serious side effects","quote":"Uncontrollable excessive urges and behaviours such as gambling, excessive eating, shopping or having sex … Confusion, high fever, severe muscle stiffness, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome)","accessed":"2026-08-27"},{"id":"hh_ari_avoid","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: what food or medication should I avoid","quote":"Avoid drinking alcohol while taking Aripiprazole as it can cause excessive sleepiness.","accessed":"2026-08-27"},{"id":"hh_ari_young","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/aripiprazole","label":"HealthHub — Aripiprazole: important warning for people under 25","quote":"In some cases, particularly in young people below the age of 25 years, this medication may cause … New or worsening thoughts of harming yourself or ending your life; Worsening agitation, restlessness, violent behaviour","accessed":"2026-08-27"},{"id":"fda_abilify_max","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ABILIFY%22&limit=1","label":"US FDA label for ABILIFY (aripiprazole), section 2 dosage table, via openFDA (Otsuka America, effective 2025-01-29)","quote":"Initial Dose Recommended Dose Maximum Dose Schizophrenia – adults 10 to 15 mg/day 10 to 15 mg/day 30 mg/day … Major Depressive Disorder – adults: adjunct to antidepressants 2 to 5 mg/day 5 to 10 mg/day 15 mg/day","accessed":"2026-08-27"},{"id":"fda_abilify_cyp","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22ABILIFY%22&limit=1","label":"US FDA label for ABILIFY, section 2.6 Dosage Adjustments for Cytochrome P450 Considerations, via openFDA","quote":"Known CYP2D6 Poor Metabolizers Administer half of usual dose … taking concomitant strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin) Administer a quarter of usual dose … Strong CYP2D6 (e.g., quinidine, fluoxetine, paroxetine)","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}