{"ok":true,"entry":{"slug":"amlodipine","kind":"medication","name":"amlodipine","aliases":["Norvasc","Amlo"],"brands_sg":["Norvasc","Sunvasc","Amcardia","Amcad","Zynor"],"class":"calcium channel blocker","tags":["heart-bp"],"use_for":"prescribed for high blood pressure and angina","use_after":"nhs: once a day, at the same time every day","use_duration":null,"take_with":"water · nhs: before or after eating, but no grapefruit","pros":["nhs: once a day, before or after eating","healthhub: relaxes and widens blood vessels","nhs: a liquid form exists; children over 6 can take it"],"cons":["nhs: ankle, foot and leg swelling is common","nhs: headaches, dizziness, flushing, palpitations","nhs: not usually recommended during pregnancy"],"dose_note":"the us fda label for norvasc states 'The usual initial antihypertensive oral dose of NORVASC is 5 mg once daily, and the maximum dose is 10 mg once daily' — 10 mg once daily is the adult label maximum, and the label gives 5–10 mg for angina and coronary artery disease and notes that in children 'Doses in excess of 5 mg daily have not been studied'. sg-registered single-ingredient tablets are 5 mg and 10 mg. in singapore the prescriber sets the dose.","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["low blood pressure, or heart failure (nhs)","a recent heart attack, or heart valve disease (nhs)","pregnancy or breastfeeding — nhs: not usually used","a past reaction to amlodipine or a similar medicine (nhs)"],"clashes":[{"src":["nhs_amlo_food","hh_amlo_interactions"],"food":true,"note":"nhs and healthhub: it can increase the chance of side effects","with":"grapefruit and grapefruit juice"},{"src":["nhs_amlo_mix"],"note":"nhs lists simvastatin among medicines that may not mix well with amlodipine","with":"simvastatin"},{"src":["nhs_amlo_mix"],"note":"nhs lists other blood pressure medicines among those that may not mix well","with":"other blood pressure medicines"},{"src":["nhs_amlo_mix"],"note":"nhs lists these antibiotics, antifungals and hiv medicines among those that may not mix well","with":"rifampicin, fluconazole, hiv medicines"},{"src":["nhs_amlo_mix"],"note":"nhs lists immunosuppressants and st john's wort among medicines that may not mix well","with":"ciclosporin, tacrolimus, st john's wort"}],"sources":[{"id":"hsa_register","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA — Listing of Registered Therapeutic Products (data.gov.sg open dataset, 5,511 rows, pulled in full via datastore_search and filtered locally)","quote":"All 86 registered amlodipine products (35 single-ingredient) carry Forensicclassification 'Prescription Only' — SIN05277P NORVASC TABLET 5 mg · SIN14005P SUNVASC · SIN14583P AMCARDIA · SIN14529P AMCAD · SIN14213P Zynor","accessed":"2026-08-27"},{"id":"nhs_amlo_about","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: what amlodipine is for","quote":"Amlodipine is a medicine used to treat high blood pressure and angina. It's only available with a prescription … a type of medicine called a calcium-channel blocker.","accessed":"2026-08-27"},{"id":"nhs_amlo_howto","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: how to take amlodipine","quote":"Amlodipine comes as tablets or a liquid that you swallow. You'll usually need to take it once a day, at the same time every day. You can take it before or after eating or drinking.","accessed":"2026-08-27"},{"id":"nhs_amlo_side","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: side effects","quote":"Common side effects of amlodipine include: swelling in your ankles, feet and legs (oedema); headaches, dizziness and feeling sleepy; a fast heartbeat … flushing … tummy pain and feeling sick (nausea)","accessed":"2026-08-27"},{"id":"nhs_amlo_who","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: who can and cannot take it, pregnancy and breastfeeding","quote":"Most adults and children over the age of 6 can take amlodipine … it may not be suitable if: … you have low blood pressure … heart failure … a recent heart attack … a history of heart valve disease","accessed":"2026-08-27"},{"id":"nhs_amlo_mix","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: taking it with other medicines","quote":"simvastatin, which is a type of statin; some antibiotics, such as rifampicin; other blood pressure medicines; some medicines to treat fungal infections, such as fluconazole … ciclosporin or tacrolimus; … St John's wort","accessed":"2026-08-27"},{"id":"nhs_amlo_food","url":"https://www.nhs.uk/medicines/amlodipine/","label":"NHS Medicines A-Z — Amlodipine: food and alcohol","quote":"Do not eat grapefruit or drink grapefruit juice while taking amlodipine because it can increase the chance of side effects.","accessed":"2026-08-27"},{"id":"hh_amlo_uses","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amlodipine","label":"HealthHub (Pharmaceutical Society of Singapore) — Amlodipine: what is this medication for","quote":"Amlodipine lowers your blood pressure by relaxing and widening blood vessels.","accessed":"2026-08-27"},{"id":"hh_amlo_interactions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amlodipine","label":"HealthHub — Amlodipine: what food or medication should I avoid","quote":"Avoid taking grapefruit when you are taking this medicine as grapefruit may interact with your medicine and increase the risk of side-effects.","accessed":"2026-08-27"},{"id":"fda_norvasc_dose","url":"https://api.fda.gov/drug/label.json?search=openfda.brand_name:%22NORVASC%22&limit=1","label":"US FDA label for NORVASC (amlodipine besylate), section 2 Dosage and Administration, via openFDA drug/label.json (effective 2023-02-15)","quote":"The usual initial antihypertensive oral dose of NORVASC is 5 mg once daily, and the maximum dose is 10 mg once daily … Doses in excess of 5 mg daily have not been studied in pediatric patients","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}