{"ok":true,"entry":{"slug":"amiodarone","kind":"medication","name":"amiodarone","aliases":["Cordarone","amiodarone hydrochloride"],"brands_sg":["Cordarone","Diolux"],"class":"class III antiarrhythmic","tags":["heart-bp"],"use_for":"abnormal heart rhythms not responding to other treatments","use_after":"after food per healthhub · hospital or specialist initiation","use_duration":null,"take_with":"food · healthhub says grapefruit may raise side-effect risk","pros":["works when other rhythm drugs cannot be used","healthhub: corrects rhythm and slows a fast heartbeat","long half-life — a missed dose changes little"],"cons":["thyroid, eye, nerve, skin and lung effects reported","prescription only in sg — all 3 registrations","sg label: hospital or specialist supervision to start"],"dose_note":"the singapore cordarone tablet 200 mg label [SIN09784P] reads 'treatment should be started with 200mg, three times a day and may be continued for 1 week. The dosage should then be reduced to 200mg, twice daily for a further week', and for maintenance 'the minimum effective dosage should be used according to individual response. It may range between 100mg daily to 400mg daily' — the largest amount the label states is 200 mg three times a day (600 mg) in the first week, and the label frames even that as temporary: 'it is particularly important that the minimum effective dose be used'; the same label says 'the safety and efficacy of amiodarone in children has not been established' and that one 200 mg tablet contains about 75 mg iodine; as directed on the label or by your doctor or pharmacist","dosage":null,"ul_status":null,"sg_class":"prescription-only","cautions":["allergic to iodine or to amiodarone — healthhub says say so first","thyroid or liver problems — healthhub says say so first","pregnant, planning to be, or breastfeeding — the sg label contraindicates both","sinus bradycardia or severe conduction problems — the sg label needs a pacemaker first"],"clashes":[{"src":["healthhub_amio_precautions"],"food":true,"note":"healthhub says these may interact and increase the risk of side effects","with":"grapefruit and grapefruit juice"},{"src":["ndf_cordarone"],"note":"the sg cordarone label states this combination is contraindicated","with":"drugs that may induce torsades de pointes"},{"src":["healthhub_amio_precautions"],"note":"healthhub names these as examples that may affect amiodarone or raise side-effect risk","with":"ritonavir, clarithromycin, erythromycin, itraconazole, ketoconazole"}],"sources":[{"id":"ndf_cordarone","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09784p/","label":"MOH National Drug Formulary — CORDARONE TABLET 200 MG [SIN09784P], indication, dosing and contraindications (page last updated 28 Jul 2026)","quote":"Oral Cordarone is indicated only for the treatment of severe rhythm disorders not responding to other therapies … Treatment should be started with 200mg, three times a day … It may range between 100mg daily to 400mg daily","accessed":"2026-08-27"},{"id":"ndf_cordarone_class","url":"https://www.ndf.gov.sg/about-drugs/product-information/sin09784p/","label":"MOH National Drug Formulary — CORDARONE TABLET 200 MG [SIN09784P], product information fields","quote":"Active Ingredient and Strength AMIODARONE HCL - 200 MG … Forensic Classification PRESCRIPTION ONLY MEDICINES … Prescription-only Medicines with Exemptions for Supply without Prescription NA","accessed":"2026-08-27"},{"id":"healthhub_amio","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amiodarone","label":"HealthHub (MOH Singapore) — Amiodarone medication information leaflet (article last reviewed 17 Feb 2025)","quote":"Amiodarone belongs to a class of medications called antiarrhythmics and is used to treat abnormal heart rhythms. It works by correcting the rhythm of your heartbeat and also by slowing your heartbeat if it is beating too fast … This medicine should be taken after food","accessed":"2026-08-27"},{"id":"healthhub_amio_precautions","url":"https://www.healthhub.sg/medication-devices-and-treatment/medications/amiodarone","label":"HealthHub (MOH Singapore) — Amiodarone, precautions, side effects and interactions sections","quote":"You are allergic to this medication, iodine … You have thyroid or liver problems … Thyroid problems … Eye problems … Nerve problems … Skin problems … Avoid taking grapefruit and grapefruit juice … Examples include: ritonavir … clarithromycin, erythromycin … itraconazole, ketoconazole","accessed":"2026-08-27"},{"id":"hsa_register_amio","url":"https://data.gov.sg/datasets/d_767279312753558cbf19d48344577084/view","label":"HSA register of therapeutic products (data.gov.sg d_767279312753558cbf19d48344577084) — 3 amiodarone rows, filtered locally from the cached copy on 27 Aug 26","quote":"CORDARONE TABLET 200 mg [SIN09784P] … Prescription Only … C01BD01 … CORDARONE INJECTION 150 mg/3 ml [SIN00852P] … Prescription Only … DIOLUX CONCENTRATE FOR SOLUTION FOR INJECTION 50MG/ML [SIN15782P] … Prescription Only","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}