{"ok":true,"entry":{"slug":"aloe-vera","kind":"supplement","name":"aloe vera","aliases":["Aloe barbadensis","aloe gel","aloe latex"],"brands_sg":["NOW Foods","Lily of the Desert","Nature's Way","Dynamic Health","Real Aloe"],"class":"botanical","tags":["gut","skin-hair"],"use_for":"sold for skin and gut · topical burn data is strongest","use_after":null,"use_duration":null,"take_with":"gel, juice or capsules · gel and latex differ","pros":["clinical research: gel may speed burn healing","oral gel up to 42 days looked safe in studies","two small studies: gel may improve acne"],"cons":["aloe latex by mouth: cramps, pain, diarrhoea","leaf extracts linked to cases of acute hepatitis","iarc: whole-leaf extract possibly carcinogenic"],"dose_note":"nccih states no standard dose; it describes short-term oral use of aloe gel up to 42 days as safe, and a 2023 review it cites covered drinkable products holding no more than 10 ppm of aloin. the us fda removed aloe latex from otc laxative products in 2002 for lack of safety data. no rda, ul or fda daily value exists for aloe, and hsa's tables 4–5 cover vitamins and minerals only, so no sg daily maximum applies","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["pregnant or breastfeeding — oral aloe may be unsafe","on digoxin — overuse of aloe latex raises adverse-effect risk","non-decolorized whole-leaf extract — iarc possible carcinogen","singapore: not listed in hsa annex a or b, which is not a safety clearance"],"clashes":[{"src":["nccih_aloe_interaction"],"note":"nccih: overuse of aloe latex may increase the risk of adverse effects","with":"digoxin and other cardiac glycosides"}],"sources":[{"id":"nccih_aloe","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera: Usefulness and Safety (last updated February 2025), promoted uses","quote":"Topical use of aloe is promoted for acne, psoriasis, lichen planus … burns, and skin damage from radiation therapy. Oral use of aloe is promoted for weight loss, diabetes, and inflammatory bowel disease","accessed":"2026-08-27"},{"id":"nccih_aloe_parts","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, parts of the leaf used","quote":"Aloe products can be made from various parts of the aloe leaf, including the gel (from the inner leaf), latex (from the leaf's outer layer), and whole crushed leaf (containing the gel and latex).","accessed":"2026-08-27"},{"id":"nccih_aloe_evidence","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, what have we learned","quote":"Clinical research suggests topical application of aloe gel may speed burn healing and reduce burn-related pain … Two small studies suggest that topical application of aloe gel, in combination with other forms of treatment, may improve acne.","accessed":"2026-08-27"},{"id":"nccih_aloe_safety","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, what do we know about safety","quote":"Research studies suggest that short-term use of oral aloe gel up to 42 days is safe. Oral use of aloe latex can cause abdominal pain, cramps, and diarrhea.","accessed":"2026-08-27"},{"id":"nccih_aloe_hepatitis","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, liver injury reports","quote":"Oral consumption of aloe leaf extracts (for as little as 3 weeks and as long as 5 years) has been related to cases of acute hepatitis.","accessed":"2026-08-27"},{"id":"nccih_aloe_iarc","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, IARC classification of whole leaf extract","quote":"The International Agency for Research on Cancer has classified whole leaf extract of aloe vera as a possible carcinogen in humans. (This form, called non-decolorized, has not undergone activated carbon treatment to remove toxic anthraquinone components.)","accessed":"2026-08-27"},{"id":"nccih_aloe_genotox","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, 2023 review of drinkable aloe products","quote":"A 2023 review looked at … commercially available food-grade drinkable products containing no more than 10 parts per million of aloin (a type of anthraquinone). The authors … concluded that the drinkable products were not genotoxic.","accessed":"2026-08-27"},{"id":"nccih_aloe_fda","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, 2002 FDA ruling on aloe latex laxatives","quote":"In 2002, the U.S. Food and Drug Administration issued a ruling that required manufacturers to remove aloe latex from over-the-counter laxative products because of a lack of safety data.","accessed":"2026-08-27"},{"id":"nccih_aloe_interaction","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, interaction with cardiac glycosides","quote":"Overuse of aloe latex may increase the risk of adverse effects from cardiac glycosides, such as digoxin, which are used for some heart problems.","accessed":"2026-08-27"},{"id":"nccih_aloe_pregnancy","url":"https://www.nccih.nih.gov/health/aloe-vera","label":"NIH NCCIH — Aloe Vera, pregnancy and breastfeeding","quote":"Aloe—in gel, latex, or whole leaf extract form—when taken by mouth may be unsafe during pregnancy and while breastfeeding.","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025), Annex A (118 rows, Abrus to Zinc) and Annex B (4 rows) — both searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"hsa_hs_limits","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA Singapore — Health Supplements Guidelines (January 2026), clause 4.8 and Tables 4–5 (vitamins and minerals only)","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/aloe-vera","label":"iHerb Singapore — Supplements > Gut Health > Aloe Vera Juice & Supplements category page, default order (1 - 46 of 46 results); first 5 distinct brands: NOW Foods, Lily of the Desert, Nature's Way, Dynamic Health, Real Aloe","quote":"NOW Foods, DGL with Aloe Vera, 400 mg … Lily of the Desert, Aloe Vera Juice, Inner Fillet … Nature's Way, Aloe Vera Leaf Juice … Dynamic Health, Aloe Vera Juice … Real Aloe, Aloe Vera Gel","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}