{"ok":true,"entry":{"slug":"ahcc","kind":"supplement","name":"AHCC","aliases":["active hexose correlated compound"],"brands_sg":["Quality of Life","American Biosciences","Protocol for Life Balance"],"class":"mushroom extract","tags":["immune"],"use_for":"immune function — evidence is one small phase ii trial","use_after":null,"use_duration":"the trial ran 6 months of once-daily use","take_with":"empty stomach · how the published trial dosed it","pros":["3 g once daily was well tolerated in the trial","the one human trial ran a full 6 months"],"cons":["evidence is one small phase ii trial","the trial was in women with persistent hpv","hsa's numeric limits cover vitamins/minerals only"],"dose_note":"the one published human trial used 3 g a day on an empty stomach for 6 months","dosage":{"ul":null,"unit":"g","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["immune-modulating medicines — the trial excluded those users","not on hsa's prohibited/restricted lists — which are not exhaustive"],"clashes":[],"sources":[{"id":"smith2022","url":"https://europepmc.org/article/PMC/PMC9256908","label":"AHCC® Supplementation to Support Immune Function to Clear Persistent HPV Infections (Smith et al., Front Oncol 2022)","quote":"AHCC supplementation of 3 g by mouth on an empty stomach once daily for 6 months … this phase II study demonstrated that AHCC 3 g once daily was effective … to eliminate persistent HPV infections and was well tolerated","accessed":"2026-08-27"},{"id":"smith2022_elig","url":"https://europepmc.org/article/PMC/PMC9256908","label":"Smith et al., Front Oncol 2022 — same trial, eligibility/exclusion criteria","quote":"Women with immunosuppressive conditions (i.e., HIV+ and rheumatoid arthritis) or taking immune modulation mediations (i.e., immunosuppressants). • Women currently taking other immune-modulating nutritional supplements.","accessed":"2026-08-27"},{"id":"hsa_hs","url":"https://file.go.gov.sg/hsa-hs-guidelines.pdf","label":"HSA — Health Supplements Guidelines (Jan 2026), Tables 4–5 vitamin and mineral limits","quote":"HS for use by the general adult population should not contain vitamins and minerals exceeding the stipulated limits stated in Tables 4 and 5.","accessed":"2026-08-27"},{"id":"hsa_pr","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines (Oct 2025)","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/ahcc","label":"iHerb Singapore — AHCC category page","quote":"AHCC for Immune Health | iHerb","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}