{"ok":true,"entry":{"slug":"agaricus","kind":"supplement","name":"agaricus","aliases":["Agaricus blazei","royal sun agaricus"],"brands_sg":["California Gold Nutrition","Quality of Life","Yerba Prima","Swanson Vitamins","Paradise Herbs"],"class":"mushroom","tags":["immune"],"use_for":"limited human evidence — one pilot trial in patients","use_after":null,"use_duration":"the pilot trial ran 28 days after surgery","take_with":null,"pros":["a 66-person randomized double-blind pilot exists","t and b cell counts held up better than placebo"],"cons":["the product tested was a multivitamin, not agaricus","the main nk-activity outcome missed significance","case report: liver injury linked to agaricus powder"],"dose_note":"no dose is established; the one randomized trial sourced here gave a multivitamin and mineral complex containing agaricus blazei for 28 days after lung surgery and its abstract states no agaricus amount, so no figure can be quoted","dosage":{"ul":null,"unit":"mg","fda_dv":null,"rda_ai":null,"ul_status":"none_established","population":"general adult","hsa_max_daily":null},"ul_status":"none_established","sg_class":null,"cautions":["liver problems — a case report links grade 3 hepatic cytolysis and cholestasis to a mushroom powder containing agaricus blazei, with liver function improving after it was stopped","on cancer treatment — that case arose during chemotherapy, and the trial evidence is in post-surgical patients","the trial product contained vitamins and minerals as well as agaricus, so its immune result cannot be assigned to agaricus","not listed in hsa's annex a/b — hsa says that list is not exhaustive"],"clashes":[{"src":["ab_liver2025","ab_liver2025_outcome"],"note":"a case report describes grade 3 hepatic cytolysis and cholestasis during chemotherapy in a woman self-medicating with a mushroom powder containing agaricus blazei; liver function improved after stopping it","with":"chemotherapy"}],"sources":[{"id":"ab_nsclc2025_design","url":"https://europepmc.org/article/PMC/PMC12839190","label":"Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer (Biomedicines 2025) — design","quote":"In this randomized, double-blind, placebo-controlled multicenter pilot trial, 66 patients with stage I-III NSCLC received either a supplement or a placebo for 28 days post-surgery.","accessed":"2026-08-27"},{"id":"ab_nsclc2025_result","url":"https://europepmc.org/article/PMC/PMC12839190","label":"Agaricus blazei multivitamin pilot trial, Biomedicines 2025 — results","quote":"Although the increase in NKA was not statistically significant, the treatment group showed a greater relative recovery (17.8% vs. 9.9%, p = 0.104). Immune profiling demonstrated significantly better preservation of T cells and B cells","accessed":"2026-08-27"},{"id":"ab_nsclc2025_multi","url":"https://europepmc.org/article/PMC/PMC12839190","label":"Agaricus blazei multivitamin pilot trial, Biomedicines 2025 — what was actually tested","quote":"This study aimed to evaluate whether multivitamin and mineral complexes containing Agaricus blazei could support postoperative immune recovery.","accessed":"2026-08-27"},{"id":"ab_liver2025","url":"https://europepmc.org/article/MED/39223928","label":"Grade 3 cytolysis in a patient with metastatic colorectal cancer consuming a mushroom powder-based alternative therapy (J Oncol Pharm Pract 2025)","quote":"Here, we report a case of cytolysis and hepatic cholestasis in a patient who was self-medicated with a mushroom powder-based alternative therapy containing Agaricus blazei Murril (ABM) during cancer treatment.","accessed":"2026-08-27"},{"id":"ab_liver2025_outcome","url":"https://europepmc.org/article/MED/39223928","label":"Agaricus blazei hepatic cytolysis case report, J Oncol Pharm Pract 2025 — attribution","quote":"given the improvement in liver function after CAM discontinuation, hepatic cytolysis appeared to be linked to ABM consumption despite the patient's liver metastases","accessed":"2026-08-27"},{"id":"hsa_pr_notlisted","url":"https://file.go.gov.sg/hsa-chp-prohibited-restricted-ing-guidelines.pdf","label":"HSA — Guidelines on Prohibited and Restricted Ingredients in Health Supplements and Traditional Medicines, GL-CHPB-1-012 Rev. No. 001 (Oct 2025), Annex A/B — searched, no row for this ingredient","quote":"The objective of this guideline is to highlight the substances of concern when used in HS and TM and is not meant to be an exhaustive list.","accessed":"2026-08-27"},{"id":"iherb_sg","url":"https://sg.iherb.com/c/agaricus","label":"iHerb Singapore — Agaricus category (default order, 10 results); first 5 distinct brands: California Gold Nutrition, Quality of Life, Yerba Prima, Swanson Vitamins, Paradise Herbs","quote":"California Gold Nutrition, Fungiology, MushRex Plus … Quality of Life, Deodorex® with Champex® Mushroom Extract … Yerba Prima, Odor Cleanse … Swanson Vitamins, Agaricus Blazei Mushroom Extract, 500 mg … Paradise Herbs, Beta Glucans","accessed":"2026-08-27"}],"brand_certs":null,"updated_at":"2026-08-29T16:16:10.48466+08:00"},"disclaimer":"kozen-x is not a medical device and does not give medical advice. it lists what published sources have written down. absence of a record is not the same as safe."}